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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Endothelium


Psychiatry related information on Endothelium


High impact information on Endothelium


Chemical compound and disease context of Endothelium


Biological context of Endothelium


Anatomical context of Endothelium


Associations of Endothelium with chemical compounds

  • We repeated the measurements after an infusion of ketanserin, an antagonist of serotonin receptors that is thought to block the effect of serotonin on receptors in the arterial wall but not in the endothelium [25].
  • Prostacyclin production may be low in healthy persons because there is almost no stimulus for its production but enhanced in patients with severe atherosclerosis as a consequence of platelet interactions with endothelium or other vascular insults [30].
  • BACKGROUND: Endothelin is a powerful vasoconstrictor peptide derived from the endothelium [31].
  • The nucleotide uridine adenosine tetraphosphate (Up(4)A) was isolated from the supernatant of stimulated human endothelium and identified by mass spectrometry [32].
  • The nitrovasodilators are another class of relaxants which exert their effects through the formation of cyclic GMP, although their relaxation is independent of the presence of the endothelium [24].

Gene context of Endothelium

  • Although CD36 has a widespread distribution on microvascular endothelium, it may not be expressed on all capillary beds where sequestration occurs, especially in the brain [33].
  • CD44 is a tightly regulated cell adhesion molecule present on leukocytes and implicated in their attachment to endothelium during an inflammatory immune response [34].
  • EPAS1 expression is limited to the endothelium of mouse embryos and, in agreement with its cell type-specific expression pattern, is capable of specifically activating the transcription of the endothelial tyrosine kinase gene Tie-2 [35].
  • Dll4, a novel Notch ligand expressed in arterial endothelium [36].
  • P-selectin glycoprotein ligand 1 (PSGL-1) is a leukocyte adhesion molecule involved in cell tether and rolling on activated endothelium [37].

Analytical, diagnostic and therapeutic context of Endothelium


  1. The binding site on ICAM-1 for Plasmodium falciparum-infected erythrocytes overlaps, but is distinct from, the LFA-1-binding site. Berendt, A.R., McDowall, A., Craig, A.G., Bates, P.A., Sternberg, M.J., Marsh, K., Newbold, C.I., Hogg, N. Cell (1992) [Pubmed]
  2. Eosinophil adhesion to nasal polyp endothelium is P-selectin-dependent. Symon, F.A., Walsh, G.M., Watson, S.R., Wardlaw, A.J. J. Exp. Med. (1994) [Pubmed]
  3. Hypoxia induces endothelin gene expression and secretion in cultured human endothelium. Kourembanas, S., Marsden, P.A., McQuillan, L.P., Faller, D.V. J. Clin. Invest. (1991) [Pubmed]
  4. Detection and partial characterization of an inhibitor of plasminogen activator in human platelets. Erickson, L.A., Ginsberg, M.H., Loskutoff, D.J. J. Clin. Invest. (1984) [Pubmed]
  5. Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. Clarkson, P., Adams, M.R., Powe, A.J., Donald, A.E., McCredie, R., Robinson, J., McCarthy, S.N., Keech, A., Celermajer, D.S., Deanfield, J.E. J. Clin. Invest. (1996) [Pubmed]
  6. Alzheimer's disease and angiogenesis. Vagnucci, A.H., Li, W.W. Lancet (2003) [Pubmed]
  7. beta-Amyloid protein immunoreactivity in skin is not a reliable marker of Alzheimer's disease. An autopsy-controlled study. Heinonen, O., Soininen, H., Syrjänen, S., Neittaanmäki, H., Paljärvi, L., Kosunen, O., Syrjänen, K., Riekkinen, P. Arch. Neurol. (1994) [Pubmed]
  8. Ethanol affects sympathetic cotransmission and endothelium-dependent relaxation in the rat. Brizzolara, A.L., Morris, D.G., Burnstock, G. Eur. J. Pharmacol. (1994) [Pubmed]
  9. Release of prostaglandins during the contraction of rat aorta induced by ouabain and K+-free solution. Satoh, T., Karaki, H. Jpn. J. Pharmacol. (1988) [Pubmed]
  10. Annexins: from structure to function. Gerke, V., Moss, S.E. Physiol. Rev. (2002) [Pubmed]
  11. Regulation of the cerebral circulation: role of endothelium and potassium channels. Faraci, F.M., Heistad, D.D. Physiol. Rev. (1998) [Pubmed]
  12. Paracrine regulation of the renal microcirculation. Navar, L.G., Inscho, E.W., Majid, S.A., Imig, J.D., Harrison-Bernard, L.M., Mitchell, K.D. Physiol. Rev. (1996) [Pubmed]
  13. Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins. Hiraoka, N., Allen, E., Apel, I.J., Gyetko, M.R., Weiss, S.J. Cell (1998) [Pubmed]
  14. Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2. Johnson, D.W., Berg, J.N., Baldwin, M.A., Gallione, C.J., Marondel, I., Yoon, S.J., Stenzel, T.T., Speer, M., Pericak-Vance, M.A., Diamond, A., Guttmacher, A.E., Jackson, C.E., Attisano, L., Kucherlapati, R., Porteous, M.E., Marchuk, D.A. Nat. Genet. (1996) [Pubmed]
  15. Elevated glucose promotes generation of endothelium-derived vasoconstrictor prostanoids in rabbit aorta. Tesfamariam, B., Brown, M.L., Deykin, D., Cohen, R.A. J. Clin. Invest. (1990) [Pubmed]
  16. Endothelium-dependent inhibition of Na(+)-K+ ATPase activity in rabbit aorta by hyperglycemia. Possible role of endothelium-derived nitric oxide. Gupta, S., Sussman, I., McArthur, C.S., Tornheim, K., Cohen, R.A., Ruderman, N.B. J. Clin. Invest. (1992) [Pubmed]
  17. Impaired muscarinic endothelium-dependent relaxation and cyclic guanosine 5'-monophosphate formation in atherosclerotic human coronary artery and rabbit aorta. Bossaller, C., Habib, G.B., Yamamoto, H., Williams, C., Wells, S., Henry, P.D. J. Clin. Invest. (1987) [Pubmed]
  18. Intensive insulin therapy protects the endothelium of critically ill patients. Langouche, L., Vanhorebeek, I., Vlasselaers, D., Vander Perre, S., Wouters, P.J., Skogstrand, K., Hansen, T.K., Van den Berghe, G. J. Clin. Invest. (2005) [Pubmed]
  19. Interleukin 1 (IL-1)-dependent melanoma hepatic metastasis in vivo; increased endothelial adherence by IL-1-induced mannose receptors and growth factor production in vitro. Vidal-Vanaclocha, F., Alvarez, A., Asumendi, A., Urcelay, B., Tonino, P., Dinarello, C.A. J. Natl. Cancer Inst. (1996) [Pubmed]
  20. Cloning of GMP-140, a granule membrane protein of platelets and endothelium: sequence similarity to proteins involved in cell adhesion and inflammation. Johnston, G.I., Cook, R.G., McEver, R.P. Cell (1989) [Pubmed]
  21. Differential inhibition by aspirin of vascular and platelet prostaglandin synthesis in atherosclerotic patients. Weksler, B.B., Pett, S.B., Alonso, D., Richter, R.C., Stelzer, P., Subramanian, V., Tack-Goldman, K., Gay, W.A. N. Engl. J. Med. (1983) [Pubmed]
  22. Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes. Smith, J.D., Chitnis, C.E., Craig, A.G., Roberts, D.J., Hudson-Taylor, D.E., Peterson, D.S., Pinches, R., Newbold, C.I., Miller, L.H. Cell (1995) [Pubmed]
  23. The nature of endothelium-derived vascular relaxant factor. Griffith, T.M., Edwards, D.H., Lewis, M.J., Newby, A.C., Henderson, A.H. Nature (1984) [Pubmed]
  24. Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation. Rapoport, R.M., Draznin, M.B., Murad, F. Nature (1983) [Pubmed]
  25. Divergent effects of serotonin on coronary-artery dimensions and blood flow in patients with coronary atherosclerosis and control patients. Golino, P., Piscione, F., Willerson, J.T., Cappelli-Bigazzi, M., Focaccio, A., Villari, B., Indolfi, C., Russolillo, E., Condorelli, M., Chiariello, M. N. Engl. J. Med. (1991) [Pubmed]
  26. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. Ludmer, P.L., Selwyn, A.P., Shook, T.L., Wayne, R.R., Mudge, G.H., Alexander, R.W., Ganz, P. N. Engl. J. Med. (1986) [Pubmed]
  27. CD36 directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Oquendo, P., Hundt, E., Lawler, J., Seed, B. Cell (1989) [Pubmed]
  28. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Plate, K.H., Breier, G., Weich, H.A., Risau, W. Nature (1992) [Pubmed]
  29. Rapid neutrophil adhesion to activated endothelium mediated by GMP-140. Geng, J.G., Bevilacqua, M.P., Moore, K.L., McIntyre, T.M., Prescott, S.M., Kim, J.M., Bliss, G.A., Zimmerman, G.A., McEver, R.P. Nature (1990) [Pubmed]
  30. Increased prostacyclin biosynthesis in patients with severe atherosclerosis and platelet activation. FitzGerald, G.A., Smith, B., Pedersen, A.K., Brash, A.R. N. Engl. J. Med. (1984) [Pubmed]
  31. The effect of an endothelin-receptor antagonist, bosentan, on blood pressure in patients with essential hypertension. Bosentan Hypertension Investigators. Krum, H., Viskoper, R.J., Lacourciere, Y., Budde, M., Charlon, V. N. Engl. J. Med. (1998) [Pubmed]
  32. Uridine adenosine tetraphosphate: a novel endothelium- derived vasoconstrictive factor. Jankowski, V., Tölle, M., Vanholder, R., Schönfelder, G., van der Giet, M., Henning, L., Schlüter, H., Paul, M., Zidek, W., Jankowski, J. Nat. Med. (2005) [Pubmed]
  33. Intercellular adhesion molecule-1 is an endothelial cell adhesion receptor for Plasmodium falciparum. Berendt, A.R., Simmons, D.L., Tansey, J., Newbold, C.I., Marsh, K. Nature (1989) [Pubmed]
  34. TNF-alpha induction of CD44-mediated leukocyte adhesion by sulfation. Maiti, A., Maki, G., Johnson, P. Science (1998) [Pubmed]
  35. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Tian, H., McKnight, S.L., Russell, D.W. Genes Dev. (1997) [Pubmed]
  36. Dll4, a novel Notch ligand expressed in arterial endothelium. Shutter, J.R., Scully, S., Fan, W., Richards, W.G., Kitajewski, J., Deblandre, G.A., Kintner, C.R., Stark, K.L. Genes Dev. (2000) [Pubmed]
  37. ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1. Urzainqui, A., Serrador, J.M., Viedma, F., Yáñez-Mó, M., Rodríguez, A., Corbí, A.L., Alonso-Lebrero, J.L., Luque, A., Deckert, M., Vázquez, J., Sánchez-Madrid, F. Immunity (2002) [Pubmed]
  38. Pharmacology of the endothelium in ischemia-reperfusion and circulatory shock. Lefer, A.M., Lefer, D.J. Annu. Rev. Pharmacol. Toxicol. (1993) [Pubmed]
  39. CD99 plays a major role in the migration of monocytes through endothelial junctions. Schenkel, A.R., Mamdouh, Z., Chen, X., Liebman, R.M., Muller, W.A. Nat. Immunol. (2002) [Pubmed]
  40. De novo expression of endothelial sialyl Lewis(a) and sialyl Lewis(x) during cardiac transplant rejection: superior capacity of a tetravalent sialyl Lewis(x) oligosaccharide in inhibiting L-selectin-dependent lymphocyte adhesion. Turunen, J.P., Majuri, M.L., Seppo, A., Tiisala, S., Paavonen, T., Miyasaka, M., Lemström, K., Penttilä, L., Renkonen, O., Renkonen, R. J. Exp. Med. (1995) [Pubmed]
  41. P-selectin glycoprotein ligand-1 mediates L-selectin-dependent leukocyte rolling in venules. Sperandio, M., Smith, M.L., Forlow, S.B., Olson, T.S., Xia, L., McEver, R.P., Ley, K. J. Exp. Med. (2003) [Pubmed]
  42. Distribution of heme oxygenase isoforms in rat liver. Topographic basis for carbon monoxide-mediated microvascular relaxation. Goda, N., Suzuki, K., Naito, M., Takeoka, S., Tsuchida, E., Ishimura, Y., Tamatani, T., Suematsu, M. J. Clin. Invest. (1998) [Pubmed]
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