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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Blood Vessels

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Disease relevance of Blood Vessels


Psychiatry related information on Blood Vessels


High impact information on Blood Vessels


Chemical compound and disease context of Blood Vessels


Biological context of Blood Vessels

  • After angiogenesis is initiated, antagonists of this integrin induce apoptosis of the proliferative angiogenic vascular cells, leaving preexisting quiescent blood vessels unaffected [19].
  • The chimeric peptide was efficiently taken up into blood vessels and endothelial cells, resulting in selective inhibition of acetylcholine (Ach)-induced vasodilation and nitric oxide (NO) production, respectively [20].
  • Angiogenic responses in three distinct in vivo models were enhanced in Akt1(-/-) mice; these enhanced responses were associated with impairment of blood vessel maturation and increased vascular permeability [21].
  • A possible mechanism of angiogenic synergism between PDGF-BB and FGF-2 involves upregulation of the expression of PDGF receptor (PDGFR)-alpha and PDGFR-beta by FGF-2 in newly formed blood vessels [22].
  • Our results suggest that the coagulation cascade and PAR1 modulate endothelial cell function in developing blood vessels and that thrombin's actions on endothelial cells-rather than on platelets, mesenchymal cells, or fibrinogen-contribute to vascular development and hemostasis in the mouse embryo [23].

Anatomical context of Blood Vessels


Associations of Blood Vessels with chemical compounds


Gene context of Blood Vessels

  • Our data suggest a critical role for ALK1 in the control of blood vessel development or repair [34].
  • Here we report that formation of blood vessels was abnormal, but not abolished, in heterozygous VEGF-deficient (VEGF+/-) embryos, generated by aggregation of embryonic stem (ES) cells with tetraploid embryos (T-ES) and even more impaired in homozygous VEGF-deficient (VEGF-/-) T-ES embryos, resulting in death at mid-gestation [35].
  • The defect in blood vessel formation in Arnt-/- yolk sacs is similar to the angiogenic abnormalities reported for mice deficient in vascular endothelial growth factor or tissue factor [36].
  • Rgs2-/- mice develop marked hypertension, and their blood vessels show enhanced contraction and decreased cGMP-mediated relaxation [37].
  • Transgenic overexpression of Ang2 disrupts blood vessel formation in the mouse embryo [38].

Analytical, diagnostic and therapeutic context of Blood Vessels


  1. Lactadherin promotes VEGF-dependent neovascularization. Silvestre, J.S., Théry, C., Hamard, G., Boddaert, J., Aguilar, B., Delcayre, A., Houbron, C., Tamarat, R., Blanc-Brude, O., Heeneman, S., Clergue, M., Duriez, M., Merval, R., Lévy, B., Tedgui, A., Amigorena, S., Mallat, Z. Nat. Med. (2005) [Pubmed]
  2. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Alon, T., Hemo, I., Itin, A., Pe'er, J., Stone, J., Keshet, E. Nat. Med. (1995) [Pubmed]
  3. Action of Corynebacterium ovis exotoxin on endothelial cells of blood vessels. Carne, H.R., Onon, E.O. Nature (1978) [Pubmed]
  4. Heparan sulfate degradation: relation to tumor invasive and metastatic properties of mouse B16 melanoma sublines. Nakajima, M., Irimura, T., Di Ferrante, D., Di Ferrante, N., Nicolson, G.L. Science (1983) [Pubmed]
  5. Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization. Paik, J.H., Skoura, A., Chae, S.S., Cowan, A.E., Han, D.K., Proia, R.L., Hla, T. Genes Dev. (2004) [Pubmed]
  6. Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels. Masters, C.L., Multhaup, G., Simms, G., Pottgiesser, J., Martins, R.N., Beyreuther, K. EMBO J. (1985) [Pubmed]
  7. Vascular smooth muscle actin is reduced in Alzheimer disease brain: a quantitative analysis. Ervin, J.F., Pannell, C., Szymanski, M., Welsh-Bohmer, K., Schmechel, D.E., Hulette, C.M. J. Neuropathol. Exp. Neurol. (2004) [Pubmed]
  8. Management of patients with chronic stable angina at low risk for serious cardiac events. Thadani, U. Am. J. Cardiol. (1997) [Pubmed]
  9. Protective effect of dexamethasone on enhancement of blood-brain barrier permeability caused by electroconvulsive shock. Suzuki, O., Takanohashi, M., Yagi, K. Arzneimittel-Forschung. (1976) [Pubmed]
  10. Emilin1 links TGF-beta maturation to blood pressure homeostasis. Zacchigna, L., Vecchione, C., Notte, A., Cordenonsi, M., Dupont, S., Maretto, S., Cifelli, G., Ferrari, A., Maffei, A., Fabbro, C., Braghetta, P., Marino, G., Selvetella, G., Aretini, A., Colonnese, C., Bettarini, U., Russo, G., Soligo, S., Adorno, M., Bonaldo, P., Volpin, D., Piccolo, S., Lembo, G., Bressan, G.M. Cell (2006) [Pubmed]
  11. Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly. Foo, S.S., Turner, C.J., Adams, S., Compagni, A., Aubyn, D., Kogata, N., Lindblom, P., Shani, M., Zicha, D., Adams, R.H. Cell (2006) [Pubmed]
  12. Mekk3 is essential for early embryonic cardiovascular development. Yang, J., Boerm, M., McCarty, M., Bucana, C., Fidler, I.J., Zhuang, Y., Su, B. Nat. Genet. (2000) [Pubmed]
  13. Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity. Brooks, P.C., Silletti, S., von Schalscha, T.L., Friedlander, M., Cheresh, D.A. Cell (1998) [Pubmed]
  14. Induction of platelet-derived growth factor A-chain and c-myc gene expressions by angiotensin II in cultured rat vascular smooth muscle cells. Naftilan, A.J., Pratt, R.E., Dzau, V.J. J. Clin. Invest. (1989) [Pubmed]
  15. Macrophage role in the anti-prostate cancer response to one class of antiangiogenic agents. Joseph, I.B., Isaacs, J.T. J. Natl. Cancer Inst. (1998) [Pubmed]
  16. Short-term hemodynamic effects of vasopressin V1-receptor inhibition in chronic right-sided congestive heart failure. Stone, C.K., Liang, C.S., Imai, N., Sakamoto, S., Sladek, C.D., Hood, W.B. Circulation (1988) [Pubmed]
  17. Inhibition of tissue angiotensin-converting enzyme with quinapril reduces hypoxic pulmonary hypertension and pulmonary vascular remodeling. Nong, Z., Stassen, J.M., Moons, L., Collen, D., Janssens, S. Circulation (1996) [Pubmed]
  18. Regulation of platelet membrane levels of glycoprotein VI by a platelet-derived metalloproteinase. Gardiner, E.E., Arthur, J.F., Kahn, M.L., Berndt, M.C., Andrews, R.K. Blood (2004) [Pubmed]
  19. Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Brooks, P.C., Montgomery, A.M., Rosenfeld, M., Reisfeld, R.A., Hu, T., Klier, G., Cheresh, D.A. Cell (1994) [Pubmed]
  20. In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation. Bucci, M., Gratton, J.P., Rudic, R.D., Acevedo, L., Roviezzo, F., Cirino, G., Sessa, W.C. Nat. Med. (2000) [Pubmed]
  21. Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo. Chen, J., Somanath, P.R., Razorenova, O., Chen, W.S., Hay, N., Bornstein, P., Byzova, T.V. Nat. Med. (2005) [Pubmed]
  22. Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2. Cao, R., Bråkenhielm, E., Pawliuk, R., Wariaro, D., Post, M.J., Wahlberg, E., Leboulch, P., Cao, Y. Nat. Med. (2003) [Pubmed]
  23. A role for thrombin receptor signaling in endothelial cells during embryonic development. Griffin, C.T., Srinivasan, Y., Zheng, Y.W., Huang, W., Coughlin, S.R. Science (2001) [Pubmed]
  24. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. Ludmer, P.L., Selwyn, A.P., Shook, T.L., Wayne, R.R., Mudge, G.H., Alexander, R.W., Ganz, P. N. Engl. J. Med. (1986) [Pubmed]
  25. Nitric oxide synthase activity in infantile hypertrophic pyloric stenosis. Vanderwinden, J.M., Mailleux, P., Schiffmann, S.N., Vanderhaeghen, J.J., De Laet, M.H. N. Engl. J. Med. (1992) [Pubmed]
  26. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Moncada, S., Gryglewski, R., Bunting, S., Vane, J.R. Nature (1976) [Pubmed]
  27. SSeCKS regulates angiogenesis and tight junction formation in blood-brain barrier. Lee, S.W., Kim, W.J., Choi, Y.K., Song, H.S., Son, M.J., Gelman, I.H., Kim, Y.J., Kim, K.W. Nat. Med. (2003) [Pubmed]
  28. Macrophage-induced angiogenesis is mediated by tumour necrosis factor-alpha. Leibovich, S.J., Polverini, P.J., Shepard, H.M., Wiseman, D.M., Shively, V., Nuseir, N. Nature (1987) [Pubmed]
  29. Arachidonic acid metabolites and the interactions between platelets and blood-vessel walls. Moncada, S., Vane, J.R. N. Engl. J. Med. (1979) [Pubmed]
  30. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. Rajfer, J., Aronson, W.J., Bush, P.A., Dorey, F.J., Ignarro, L.J. N. Engl. J. Med. (1992) [Pubmed]
  31. A prospective clinical and immunologic analysis of patients with serum sickness. Lawley, T.J., Bielory, L., Gascon, P., Yancey, K.B., Young, N.S., Frank, M.M. N. Engl. J. Med. (1984) [Pubmed]
  32. Preserved endothelium-dependent vasodilatation in patients with essential hypertension. Cockcroft, J.R., Chowienczyk, P.J., Benjamin, N., Ritter, J.M. N. Engl. J. Med. (1994) [Pubmed]
  33. Regulation by angiotensin II of its receptors in resistance blood vessels. Gunther, S., Gimbrone, M.A., Alexander, R.W. Nature (1980) [Pubmed]
  34. Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2. Johnson, D.W., Berg, J.N., Baldwin, M.A., Gallione, C.J., Marondel, I., Yoon, S.J., Stenzel, T.T., Speer, M., Pericak-Vance, M.A., Diamond, A., Guttmacher, A.E., Jackson, C.E., Attisano, L., Kucherlapati, R., Porteous, M.E., Marchuk, D.A. Nat. Genet. (1996) [Pubmed]
  35. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Carmeliet, P., Ferreira, V., Breier, G., Pollefeyt, S., Kieckens, L., Gertsenstein, M., Fahrig, M., Vandenhoeck, A., Harpal, K., Eberhardt, C., Declercq, C., Pawling, J., Moons, L., Collen, D., Risau, W., Nagy, A. Nature (1996) [Pubmed]
  36. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Maltepe, E., Schmidt, J.V., Baunoch, D., Bradfield, C.A., Simon, M.C. Nature (1997) [Pubmed]
  37. Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure. Tang, K.M., Wang, G.R., Lu, P., Karas, R.H., Aronovitz, M., Heximer, S.P., Kaltenbronn, K.M., Blumer, K.J., Siderovski, D.P., Zhu, Y., Mendelsohn, M.E., Tang, M., Wang, G. Nat. Med. (2003) [Pubmed]
  38. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Maisonpierre, P.C., Suri, C., Jones, P.F., Bartunkova, S., Wiegand, S.J., Radziejewski, C., Compton, D., McClain, J., Aldrich, T.H., Papadopoulos, N., Daly, T.J., Davis, S., Sato, T.N., Yancopoulos, G.D. Science (1997) [Pubmed]
  39. Structure of human methionine aminopeptidase-2 complexed with fumagillin. Liu, S., Widom, J., Kemp, C.W., Crews, C.M., Clardy, J. Science (1998) [Pubmed]
  40. Distribution of vascular permeability factor (vascular endothelial growth factor) in tumors: concentration in tumor blood vessels. Dvorak, H.F., Sioussat, T.M., Brown, L.F., Berse, B., Nagy, J.A., Sotrel, A., Manseau, E.J., Van de Water, L., Senger, D.R. J. Exp. Med. (1991) [Pubmed]
  41. Expression and localization of inducible and endothelial nitric oxide synthase in the rat ovary. Effects of gonadotropin stimulation in vivo. Van Voorhis, B.J., Moore, K., Strijbos, P.J., Nelson, S., Baylis, S.A., Grzybicki, D., Weiner, C.P. J. Clin. Invest. (1995) [Pubmed]
  42. Immunohistochemical demonstration of serotonin in nerves supplying human cerebral and mesenteric blood-vessels. Some speculations about their involvement in vascular disorders. Griffith, S.G., Burnstock, G. Lancet (1983) [Pubmed]
  43. Microcirculation of intestinal lymphoid follicles in rat Peyer's patches. Bhalla, D.K., Murakami, T., Owen, R.L. Gastroenterology (1981) [Pubmed]
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