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Gene Review:

focA - formate transporter

Escherichia coli UTI89

Sawers, R.G., Sawers, R.G.

Sawers,

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Disease relevance of focA

Expression of the anaerobically inducible focA-pflB operon of Escherichia coli is subject to complex transcriptional and post-transcriptional control, which generates eight transcripts whose 5' ends span approximately 1.2 kb [1].

High impact information on focA

Remarkably, the 5' ends of four further highly abundant operon-internal transcripts are located within the focA gene, with a fifth transcript mapping in the intergenic region between focA and pfl [2].
Transcript analysis throughout the growth phase revealed that maximal anaerobic expression of the focA-pflB operon was restricted to exponentially growing cells [1].

References

Differential turnover of the multiple processed transcripts of the Escherichia coli focA-pflB operon. Sawers, R.G. Microbiology (Reading, Engl.) (2006) [Pubmed]
Evidence for novel processing of the anaerobically inducible dicistronic focA-pfl mRNA transcript in Escherichia coli. Sawers, R.G. Mol. Microbiol. (2005) [Pubmed]

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