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Gene Review

set-a  -  SET nuclear oncogene

Xenopus laevis

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High impact information on SET

  • Human TAF-Ibeta has a chromatin decondensation activity comparable to that of NAP-I, another histone binding protein, whereas TAF-Ialpha has only a weak activity [1].
  • TAF-I beta corresponds to the protein encoded by the set gene, which was found in an acute undifferentiated leukemia as a fusion version with the can gene via chromosomal translocation [2].


  1. Sperm chromatin decondensation by template activating factor I through direct interaction with basic proteins. Matsumoto, K., Nagata, K., Miyaji-Yamaguchi, M., Kikuchi, A., Tsujimoto, M. Mol. Cell. Biol. (1999) [Pubmed]
  2. Cellular localization and expression of template-activating factor I in different cell types. Nagata, K., Saito, S., Okuwaki, M., Kawase, H., Furuya, A., Kusano, A., Hanai, N., Okuda, A., Kikuchi, A. Exp. Cell Res. (1998) [Pubmed]
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