The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Translocation, Genetic

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Translocation, Genetic


Psychiatry related information on Translocation, Genetic


High impact information on Translocation, Genetic


Chemical compound and disease context of Translocation, Genetic


Biological context of Translocation, Genetic


Anatomical context of Translocation, Genetic


Associations of Translocation, Genetic with chemical compounds

  • CML cells carrying the t(9;22) chromosomal translocation are known to produce an 8-kilobase (kb) c-abl transcript in addition to the normal 6- and 7-kb transcripts and to express the normal p145 abl protein and a p210 c-abl protein possessing a tyrosine kinase activity not detected in the p145 species [28].
  • Retinoid effects seem to result from changes in gene expression mediated via specific nuclear receptors (termed retinoic acid receptors, RAR-alpha, -beta, and -gamma), and a specific chromosomal translocation involving the RAR-alpha gene occurs in APL patients [29].
  • Rh10 and Rh28 exhibit the same chromosomal translocation and express an atypical lactate dehydrogenase isoenzyme which may be homologous to those previously reported in other tumor types [30].
  • Among the aprt mutations induced in confluence-arrested Chinese hamster ovary D422 cells by the topoisomerase II poison amsacrine, there was a reciprocal exchange between the aprt gene and an unrelated sequence, accompanied by a chromosomal translocation at the aprt locus [31].
  • More than 85% of Ewing's family tumors carry a specific chromosomal translocation that fuses the NH(2) terminus of the EWS gene to the COOH terminus of the FLI1 transcription factor [32].

Gene context of Translocation, Genetic


Analytical, diagnostic and therapeutic context of Translocation, Genetic


  1. MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Armstrong, S.A., Staunton, J.E., Silverman, L.B., Pieters, R., den Boer, M.L., Minden, M.D., Sallan, S.E., Lander, E.S., Golub, T.R., Korsmeyer, S.J. Nat. Genet. (2002) [Pubmed]
  2. Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations. Thirman, M.J., Gill, H.J., Burnett, R.C., Mbangkollo, D., McCabe, N.R., Kobayashi, H., Ziemin-van der Poel, S., Kaneko, Y., Morgan, R., Sandberg, A.A. N. Engl. J. Med. (1993) [Pubmed]
  3. Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor. Nourse, J., Mellentin, J.D., Galili, N., Wilkinson, J., Stanbridge, E., Smith, S.D., Cleary, M.L. Cell (1990) [Pubmed]
  4. A novel 6:10 chromosomal translocation in the murine plasmacytoma NS-1. Perlmutter, R.M., Klotz, J.L., Pravtcheva, D., Ruddle, F., Hood, L. Nature (1984) [Pubmed]
  5. Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. Crozat, A., Aman, P., Mandahl, N., Ron, D. Nature (1993) [Pubmed]
  6. Therapy-related acute myeloid leukemia following treatment with epipodophyllotoxins: estimating the risks. Smith, M.A., Rubinstein, L., Ungerleider, R.S. Med. Pediatr. Oncol. (1994) [Pubmed]
  7. AGTR2 mutations in X-linked mental retardation. Vervoort, V.S., Beachem, M.A., Edwards, P.S., Ladd, S., Miller, K.E., de Mollerat, X., Clarkson, K., DuPont, B., Schwartz, C.E., Stevenson, R.E., Boyd, E., Srivastava, A.K. Science (2002) [Pubmed]
  8. Genes of the T-cell antigen receptor in normal and malignant T cells. Toyonaga, B., Mak, T.W. Annu. Rev. Immunol. (1987) [Pubmed]
  9. Haploinsufficiency of NSD1 causes Sotos syndrome. Kurotaki, N., Imaizumi, K., Harada, N., Masuno, M., Kondoh, T., Nagai, T., Ohashi, H., Naritomi, K., Tsukahara, M., Makita, Y., Sugimoto, T., Sonoda, T., Hasegawa, T., Chinen, Y., Tomita Ha, H.A., Kinoshita, A., Mizuguchi, T., Yoshiura Ki, K., Ohta, T., Kishino, T., Fukushima, Y., Niikawa, N., Matsumoto, N. Nat. Genet. (2002) [Pubmed]
  10. Fusion of retinoic acid receptor alpha to NuMA, the nuclear mitotic apparatus protein, by a variant translocation in acute promyelocytic leukaemia. Wells, R.A., Catzavelos, C., Kamel-Reid, S. Nat. Genet. (1997) [Pubmed]
  11. A translocation interrupts the COL5A1 gene in a patient with Ehlers-Danlos syndrome and hypomelanosis of Ito. Toriello, H.V., Glover, T.W., Takahara, K., Byers, P.H., Miller, D.E., Higgins, J.V., Greenspan, D.S. Nat. Genet. (1996) [Pubmed]
  12. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Ellisen, L.W., Bird, J., West, D.C., Soreng, A.L., Reynolds, T.C., Smith, S.D., Sklar, J. Cell (1991) [Pubmed]
  13. In vivo and in vitro characterization of the B1 and B2 zinc-binding domains from the acute promyelocytic leukemia protooncoprotein PML. Borden, K.L., Lally, J.M., Martin, S.R., O'Reilly, N.J., Solomon, E., Freemont, P.S. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  14. Accelerated degradation of PML-retinoic acid receptor alpha (PML-RARA) oncoprotein by all-trans-retinoic acid in acute promyelocytic leukemia: possible role of the proteasome pathway. Yoshida, H., Kitamura, K., Tanaka, K., Omura, S., Miyazaki, T., Hachiya, T., Ohno, R., Naoe, T. Cancer Res. (1996) [Pubmed]
  15. Functional cooperation among Ras, STAT5, and phosphatidylinositol 3-kinase is required for full oncogenic activities of BCR/ABL in K562 cells. Sonoyama, J., Matsumura, I., Ezoe, S., Satoh, Y., Zhang, X., Kataoka, Y., Takai, E., Mizuki, M., Machii, T., Wakao, H., Kanakura, Y. J. Biol. Chem. (2002) [Pubmed]
  16. A novel pre-B acute lymphoblastic leukemia cell line with chromosomal translocation between p16(INK4A)/p15(INK4B) tumor suppressor and immunoglobulin heavy chain genes: TGFbeta/IL-7 inhibitory signaling mechanism. Urashima, M., Hoshi, Y., Sugimoto, Y., Kaihara, C., Matsuzaki, M., Chauhan, D., Ogata, A., Teoh, G., DeCaprio, J.A., Anderson, K.C. Leukemia (1996) [Pubmed]
  17. The association of the TEL-AML1 chromosomal translocation with the accumulation of methotrexate polyglutamates in lymphoblasts and with ploidy in childhood B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study. Whitehead, V.M., Payment, C., Cooley, L., Lauer, S.J., Mahoney, D.H., Shuster, J.J., Vuchich, M.J., Bernstein, M.L., Look, A.T., Pullen, D.J., Camitta, B. Leukemia (2001) [Pubmed]
  18. Rat c-myc oncogene is located on chromosome 7 and rearranges in immunocytomas with t(6:7) chromosomal translocation. Sümegi, J., Spira, J., Bazin, H., Szpirer, J., Levan, G., Klein, G. Nature (1983) [Pubmed]
  19. Altered Hox expression and segmental identity in Mll-mutant mice. Yu, B.D., Hess, J.L., Horning, S.E., Brown, G.A., Korsmeyer, S.J. Nature (1995) [Pubmed]
  20. Segmental and developmental regulation of a presumptive T-cell oncogene in the central nervous system. Greenberg, J.M., Boehm, T., Sofroniew, M.V., Keynes, R.J., Barton, S.C., Norris, M.L., Surani, M.A., Spillantini, M.G., Rabbits, T.H. Nature (1990) [Pubmed]
  21. Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development. Gao, Y., Ferguson, D.O., Xie, W., Manis, J.P., Sekiguchi, J., Frank, K.M., Chaudhuri, J., Horner, J., DePinho, R.A., Alt, F.W. Nature (2000) [Pubmed]
  22. LMO T-cell translocation oncogenes typify genes activated by chromosomal translocations that alter transcription and developmental processes. Rabbitts, T.H. Genes Dev. (1998) [Pubmed]
  23. Analysis of DNA surrounding the breakpoints of chromosomal translocations involving the beta T cell receptor gene in human lymphoblastic neoplasms. Reynolds, T.C., Smith, S.D., Sklar, J. Cell (1987) [Pubmed]
  24. IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy. Hatzivassiliou, G., Miller, I., Takizawa, J., Palanisamy, N., Rao, P.H., Iida, S., Tagawa, S., Taniwaki, M., Russo, J., Neri, A., Cattoretti, G., Clynes, R., Mendelsohn, C., Chaganti, R.S., Dalla-Favera, R. Immunity (2001) [Pubmed]
  25. BCL2 translocation frequency rises with age in humans. Liu, Y., Hernandez, A.M., Shibata, D., Cortopassi, G.A. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  26. Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias. Jaiswal, S., Traver, D., Miyamoto, T., Akashi, K., Lagasse, E., Weissman, I.L. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  27. The kinesin KIF17b and RNA-binding protein TB-RBP transport specific cAMP-responsive element modulator-regulated mRNAs in male germ cells. Chennathukuzhi, V., Morales, C.R., El-Alfy, M., Hecht, N.B. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  28. Expression of a translocated c-abl gene in hybrids of mouse fibroblasts and chronic myelogenous leukaemia cells. Kozbor, D., Giallongo, A., Sierzega, M.E., Konopka, J.B., Witte, O.N., Showe, L.C., Croce, C.M. Nature (1986) [Pubmed]
  29. Retinoids in cancer therapy. Smith, M.A., Parkinson, D.R., Cheson, B.D., Friedman, M.A. J. Clin. Oncol. (1992) [Pubmed]
  30. Characterization of cell lines derived from xenografts of childhood rhabdomyosarcoma. Hazelton, B.J., Houghton, J.A., Parham, D.M., Douglass, E.C., Torrance, P.M., Holt, H., Houghton, P.J. Cancer Res. (1987) [Pubmed]
  31. A precise interchromosomal reciprocal exchange between hot spots for cleavable complex formation by topoisomerase II in amsacrine-treated Chinese hamster ovary cells. Zhou, R.H., Wang, P., Zou, Y., Jackson-Cook, C.K., Povirk, L.F. Cancer Res. (1997) [Pubmed]
  32. The COOH-terminal domain of FLI-1 is necessary for full tumorigenesis and transcriptional modulation by EWS/FLI-1. Arvand, A., Welford, S.M., Teitell, M.A., Denny, C.T. Cancer Res. (2001) [Pubmed]
  33. A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. Lacronique, V., Boureux, A., Valle, V.D., Poirel, H., Quang, C.T., Mauchauffé, M., Berthou, C., Lessard, M., Berger, R., Ghysdael, J., Bernard, O.A. Science (1997) [Pubmed]
  34. Cytotoxic T cell response against the chimeric ETV6-AML1 protein in childhood acute lymphoblastic leukemia. Yotnda, P., Garcia, F., Peuchmaur, M., Grandchamp, B., Duval, M., Lemonnier, F., Vilmer, E., Langlade-Demoyen, P. J. Clin. Invest. (1998) [Pubmed]
  35. Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice. Larson, R.C., Lavenir, I., Larson, T.A., Baer, R., Warren, A.J., Wadman, I., Nottage, K., Rabbitts, T.H. EMBO J. (1996) [Pubmed]
  36. MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein. Xia, Z.B., Anderson, M., Diaz, M.O., Zeleznik-Le, N.J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  37. Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta. Sasaki, K., Yagi, H., Bronson, R.T., Tominaga, K., Matsunashi, T., Deguchi, K., Tani, Y., Kishimoto, T., Komori, T. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  38. A 45,X male with Y-specific DNA translocated onto chromosome 15. Gal, A., Weber, B., Neri, G., Serra, A., Müller, U., Schempp, W., Page, D.C. Am. J. Hum. Genet. (1987) [Pubmed]
  39. A novel chromosomal translocation t(4; 14)(p16.3; q32) in multiple myeloma involves the fibroblast growth-factor receptor 3 gene. Richelda, R., Ronchetti, D., Baldini, L., Cro, L., Viggiano, L., Marzella, R., Rocchi, M., Otsuki, T., Lombardi, L., Maiolo, A.T., Neri, A. Blood (1997) [Pubmed]
  40. Cabeza, a Drosophila gene encoding a novel RNA binding protein, shares homology with EWS and TLS, two genes involved in human sarcoma formation. Stolow, D.T., Haynes, S.R. Nucleic Acids Res. (1995) [Pubmed]
  41. Overexpression of AML1 renders a T hybridoma resistant to T cell receptor-mediated apoptosis. Fujii, M., Hayashi, K., Niki, M., Chiba, N., Meguro, K., Endo, K., Kameoka, J., Ito, S., Abe, K., Watanabe, T., Satake, M. Oncogene (1998) [Pubmed]
  42. The Role of LMO2 in Development and in T Cell Leukemia After Chromosomal Translocation or Retroviral Insertion. Nam, C.H., Rabbitts, T.H. Mol. Ther. (2006) [Pubmed]
WikiGenes - Universities