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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Translocation, Genetic

 
 
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Disease relevance of Translocation, Genetic

 

Psychiatry related information on Translocation, Genetic

 

High impact information on Translocation, Genetic

 

Chemical compound and disease context of Translocation, Genetic

 

Biological context of Translocation, Genetic

 

Anatomical context of Translocation, Genetic

 

Associations of Translocation, Genetic with chemical compounds

  • CML cells carrying the t(9;22) chromosomal translocation are known to produce an 8-kilobase (kb) c-abl transcript in addition to the normal 6- and 7-kb transcripts and to express the normal p145 abl protein and a p210 c-abl protein possessing a tyrosine kinase activity not detected in the p145 species [28].
  • Retinoid effects seem to result from changes in gene expression mediated via specific nuclear receptors (termed retinoic acid receptors, RAR-alpha, -beta, and -gamma), and a specific chromosomal translocation involving the RAR-alpha gene occurs in APL patients [29].
  • Rh10 and Rh28 exhibit the same chromosomal translocation and express an atypical lactate dehydrogenase isoenzyme which may be homologous to those previously reported in other tumor types [30].
  • Among the aprt mutations induced in confluence-arrested Chinese hamster ovary D422 cells by the topoisomerase II poison amsacrine, there was a reciprocal exchange between the aprt gene and an unrelated sequence, accompanied by a chromosomal translocation at the aprt locus [31].
  • More than 85% of Ewing's family tumors carry a specific chromosomal translocation that fuses the NH(2) terminus of the EWS gene to the COOH terminus of the FLI1 transcription factor [32].
 

Gene context of Translocation, Genetic

 

Analytical, diagnostic and therapeutic context of Translocation, Genetic

References

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  19. Altered Hox expression and segmental identity in Mll-mutant mice. Yu, B.D., Hess, J.L., Horning, S.E., Brown, G.A., Korsmeyer, S.J. Nature (1995) [Pubmed]
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  22. LMO T-cell translocation oncogenes typify genes activated by chromosomal translocations that alter transcription and developmental processes. Rabbitts, T.H. Genes Dev. (1998) [Pubmed]
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