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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

nedd4l  -  neural precursor cell expressed,...

Xenopus laevis

 
 
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Disease relevance of nedd4

  • The activity of ENaC is controlled by its interaction with Nedd4; mutations that disrupt this interaction increase Na+ absorption, causing an inherited form of hypertension (Liddle's syndrome) [1].
 

High impact information on nedd4

  • Nedd4 contains an N-terminal C2 domain, a C-terminal ubiquitin ligase domain, and multiple WW domains [1].
 

Analytical, diagnostic and therapeutic context of nedd4

References

  1. Multiple WW domains, but not the C2 domain, are required for inhibition of the epithelial Na+ channel by human Nedd4. Snyder, P.M., Olson, D.R., McDonald, F.J., Bucher, D.B. J. Biol. Chem. (2001) [Pubmed]
  2. Molecular cloning of Nedd4 from Xenopus laevis. Rebhun, J.F., Pratt, J.H. DNA Seq. (1998) [Pubmed]
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