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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

mutS  -  DNA mismatch repair protein MutS

Escherichia coli UTI89

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Disease relevance of mutS

 

High impact information on mutS

  • This study compared the frequencies of emerging ceftazidime resistance in isogenic wild-type and hyper-mutable mutS CTX-M-3-producing Escherichia coli strains, and sequenced the mutant bla(CTX-M) alleles selected [2].
 

Associations of mutS with chemical compounds

  • Moreover, although ceftazidime-resistant mutants, or those with reduced susceptibility, were selected in both the wild-type and mutS hosts, many more mutants in the mutS host showed ceftazidimase-type extended-spectrum beta-lactamase (ESBL) activity [1].

References

  1. Development of extended-spectrum activity in TEM beta-lactamases in hyper-mutable, mutS Escherichia coli. Ellington, M.J., Livermore, D.M., Pitt, T.L., Hall, L.M., Woodford, N. Clin. Microbiol. Infect. (2006) [Pubmed]
  2. Development of high-level ceftazidime resistance via single-base substitutions of blaCTX-M-3 in hyper-mutable Escherichia coli. Karisik, E., Ellington, M.J., Pike, R., Livermore, D.M., Woodford, N. Clin. Microbiol. Infect. (2006) [Pubmed]
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