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Gene Review:

RhoA - RhoA GTPase

Strongylocentrotus purpuratus

Bement, W.M. et al., Cuéllar-Mata, P. et al.

Bement, Benink, von Dassow,

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High impact information on RhoA

The small GTPase RhoA has previously been implicated in cytokinesis [1].
Microtubules direct the formation and placement of the RhoA activity zone, and the zone is repositioned after physical spindle displacement [1].
Cytokinetic RhoA activity zones are common to four echinoderm species, the vertebrate Xenopus laevis, and the highly asymmetric cytokinesis accompanying meiosis [1].
Immunocytochemical analyses indicated that RhoA was localized preferentially to the cortical granules; this was confirmed by experiments of [32P]ADP-ribosylation with C3 in isolated cortical granules [2].

References

A microtubule-dependent zone of active RhoA during cleavage plane specification. Bement, W.M., Benink, H.A., von Dassow, G. J. Cell Biol. (2005) [Pubmed]
The GTP-binding protein RhoA localizes to the cortical granules of Strongylocentrotus purpuratas sea urchin egg and is secreted during fertilization. Cuéllar-Mata, P., Martínez-Cadena, G., López-Godínez, J., Obregón, A., García-Soto, J. Eur. J. Cell Biol. (2000) [Pubmed]

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