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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Mi-2  -  CG8103 gene product from transcript CG8103-RA

Drosophila melanogaster

Synonyms: 0006/06, 0854/01, ATP-dependent helicase Mi-2, CG8103, Chromodomain-helicase-DNA-binding protein Mi-2 homolog, ...
 
 
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Disease relevance of Mi-2

  • Mammalian Mi-2, an auto-antigen for dermatomyositis, is known to be an adenosine triphosphate (ATP)-dependent nucleosome remodelling factor [1].
 

High impact information on Mi-2

  • Mi-2 and ISWI, two members of the Snf2 superfamily of ATPases, reside in separate ATP-dependent chromatin remodelling complexes [2].
  • Drosophila Mi-2 negatively regulates dDREF by inhibiting its DNA-binding activity [3].
  • Here, we have investigated the ATP-dependent chromatin remodeling enzyme Mi-2 of Drosophila melanogaster [4].
  • However, the MBD-like proteins exhibit transcriptional and biochemical properties consistent with roles as components of a histone deacetylase-dependent corepressor complex similar to the vertebrate Mi-2 complex [5].
 

Other interactions of Mi-2

  • This banding pattern suggests gene-specific regulatory functions for dMBD-like and the Drosophila Mi-2 complex [5].

References

  1. Genetic characterization of Drosophila Mi-2 ATPase. Khattak, S., Lee, B.R., Cho, S.H., Ahnn, J., Spoerel, N.A. Gene (2002) [Pubmed]
  2. dMi-2 and ISWI chromatin remodelling factors have distinct nucleosome binding and mobilization properties. Brehm, A., Längst, G., Kehle, J., Clapier, C.R., Imhof, A., Eberharter, A., Müller, J., Becker, P.B. EMBO J. (2000) [Pubmed]
  3. Drosophila Mi-2 negatively regulates dDREF by inhibiting its DNA-binding activity. Hirose, F., Ohshima, N., Kwon, E.J., Yoshida, H., Yamaguchi, M. Mol. Cell. Biol. (2002) [Pubmed]
  4. dMi-2 chromatin binding and remodeling activities are regulated by dCK2 phosphorylation. Bouazoune, K., Brehm, A. J. Biol. Chem. (2005) [Pubmed]
  5. A Drosophila MBD family member is a transcriptional corepressor associated with specific genes. Ballestar, E., Pile, L.A., Wassarman, D.A., Wolffe, A.P., Wade, P.A. Eur. J. Biochem. (2001) [Pubmed]
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