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Gene Review:

CHD5 - chromodomain helicase DNA binding protein 5

Homo sapiens

Synonyms: ATP-dependent helicase CHD5, CHD-5, Chromodomain-helicase-DNA-binding protein 5, KIAA0444

Thompson, P.M. et al., White, P.S. et al., Law, M.E. et al.

White, Thompson, Gotoh, Okawa, Igarashi, Kok, Winter, Gregory, Hogarty, Maris, Brodeur,

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Disease relevance of CHD5

CHD5 maps within a small region of deletion on 1p36.3 in human neuroblastomas, a common pediatric tumor [1].

High impact information on CHD5

In addition, a novel gene (CHD5) with strong homology to proteins involved in chromatin remodeling was expressed mainly in neural tissues [2].
We examined a panel of neuroblastoma cell lines for CHD5 expression, which was consistently low or undetectable in all these lines [1].
This common deletion region is localized at 1p36.31 and includes CHD5, a putative tumor suppressor gene [3].

References

CHD5, a new member of the chromodomain gene family, is preferentially expressed in the nervous system. Thompson, P.M., Gotoh, T., Kok, M., White, P.S., Brodeur, G.M. Oncogene (2003) [Pubmed]
Definition and characterization of a region of 1p36.3 consistently deleted in neuroblastoma. White, P.S., Thompson, P.M., Gotoh, T., Okawa, E.R., Igarashi, J., Kok, M., Winter, C., Gregory, S.G., Hogarty, M.D., Maris, J.M., Brodeur, G.M. Oncogene (2005) [Pubmed]
Molecular cytogenetic analysis of chromosomes 1 and 19 in glioma cell lines. Law, M.E., Templeton, K.L., Kitange, G., Smith, J., Misra, A., Feuerstein, B.G., Jenkins, R.B. Cancer Genet. Cytogenet. (2005) [Pubmed]

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AgaP_AGAP012009	Anopheles gambiae str. PEST
CHD5	Bos taurus
CHD5	Canis lupus familiaris
chd5	Danio rerio
Mi-2	Drosophila melanogaster
CHD5	Gallus gallus
Chd5	Mus musculus
Chd5	Rattus norvegicus
chd5	Xenopus (Silurana) tropicalis

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