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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Chromatin Assembly and Disassembly

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Disease relevance of Chromatin Assembly and Disassembly


High impact information on Chromatin Assembly and Disassembly


Chemical compound and disease context of Chromatin Assembly and Disassembly


Biological context of Chromatin Assembly and Disassembly


Anatomical context of Chromatin Assembly and Disassembly


Associations of Chromatin Assembly and Disassembly with chemical compounds


Gene context of Chromatin Assembly and Disassembly

  • In chromatin assembly, purified ACF and a core histone chaperone (such as NAP-1 or CAF-1) are sufficient for the ATP-dependent formation of periodic nucleosome arrays [13].
  • Similar chromatin remodeling was observed at a PHO5 promoter deleted for TATA and thus unable to support transcription [28].
  • We demonstrate that distinct forms of the yeast chromatin-remodeling enzyme Isw1p sequentially regulate each stage of the transcription cycle [29].
  • Using a combination of affinity- and conventional chromatographic techniques, we have isolated a predominant form of a multiprotein BRCA1-containing complex from human cells displaying chromatin-remodeling activity [30].
  • Thus, ASF1-dependent chromatin assembly may mediate the role of the SAS complex in silencing [31].

Analytical, diagnostic and therapeutic context of Chromatin Assembly and Disassembly


  1. Identification of acquired somatic mutations in the gene encoding chromatin-remodeling factor ATRX in the alpha-thalassemia myelodysplasia syndrome (ATMDS). Gibbons, R.J., Pellagatti, A., Garrick, D., Wood, W.G., Malik, N., Ayyub, H., Langford, C., Boultwood, J., Wainscoat, J.S., Higgs, D.R. Nat. Genet. (2003) [Pubmed]
  2. Rapid periodic binding and displacement of the glucocorticoid receptor during chromatin remodeling. Nagaich, A.K., Walker, D.A., Wolford, R., Hager, G.L. Mol. Cell (2004) [Pubmed]
  3. Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop. Kook, H., Lepore, J.J., Gitler, A.D., Lu, M.M., Wing-Man Yung, W., Mackay, J., Zhou, R., Ferrari, V., Gruber, P., Epstein, J.A. J. Clin. Invest. (2003) [Pubmed]
  4. Cell cycle arrest and repression of cyclin D1 transcription by INI1/hSNF5. Zhang, Z.K., Davies, K.P., Allen, J., Zhu, L., Pestell, R.G., Zagzag, D., Kalpana, G.V. Mol. Cell. Biol. (2002) [Pubmed]
  5. Long-term hydroxytamoxifen treatment of an MCF-7-derived breast cancer cell line irreversibly inhibits the expression of estrogenic genes through chromatin remodeling. Badia, E., Duchesne, M.J., Semlali, A., Fuentes, M., Giamarchi, C., Richard-Foy, H., Nicolas, J.C., Pons, M. Cancer Res. (2000) [Pubmed]
  6. Nuclear actin and actin-related proteins in chromatin remodeling. Olave, I.A., Reck-Peterson, S.L., Crabtree, G.R. Annu. Rev. Biochem. (2002) [Pubmed]
  7. Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone. Zhao, R., Davey, M., Hsu, Y.C., Kaplanek, P., Tong, A., Parsons, A.B., Krogan, N., Cagney, G., Mai, D., Greenblatt, J., Boone, C., Emili, A., Houry, W.A. Cell (2005) [Pubmed]
  8. Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing. Harikrishnan, K.N., Chow, M.Z., Baker, E.K., Pal, S., Bassal, S., Brasacchio, D., Wang, L., Craig, J.M., Jones, P.L., Sif, S., El-Osta, A. Nat. Genet. (2005) [Pubmed]
  9. Genome-scale profiling of histone H3.3 replacement patterns. Mito, Y., Henikoff, J.G., Henikoff, S. Nat. Genet. (2005) [Pubmed]
  10. Cisplatin inhibits chromatin remodeling, transcription factor binding, and transcription from the mouse mammary tumor virus promoter in vivo. Mymryk, J.S., Zaniewski, E., Archer, T.K. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  11. Steroid-selective initiation of chromatin remodeling and transcriptional activation of the mouse mammary tumor virus promoter is controlled by the site of promoter integration. Lambert, J.R., Nordeen, S.K. J. Biol. Chem. (1998) [Pubmed]
  12. Inhibition of histone deacetylation augments dihydrotestosterone induction of androgen receptor levels: an explanation for trichostatin A effects on androgen-induced chromatin remodeling and transcription of the mouse mammary tumor virus promoter. List, H.J., Smith, C.L., Rodriguez, O., Danielsen, M., Riegel, A.T. Exp. Cell Res. (1999) [Pubmed]
  13. ACF, an ISWI-containing and ATP-utilizing chromatin assembly and remodeling factor. Ito, T., Bulger, M., Pazin, M.J., Kobayashi, R., Kadonaga, J.T. Cell (1997) [Pubmed]
  14. Global role for chromatin remodeling enzymes in mitotic gene expression. Krebs, J.E., Fry, C.J., Samuels, M.L., Peterson, C.L. Cell (2000) [Pubmed]
  15. Genes required for ionizing radiation resistance in yeast. Bennett, C.B., Lewis, L.K., Karthikeyan, G., Lobachev, K.S., Jin, Y.H., Sterling, J.F., Snipe, J.R., Resnick, M.A. Nat. Genet. (2001) [Pubmed]
  16. Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice. Chen, R.Z., Akbarian, S., Tudor, M., Jaenisch, R. Nat. Genet. (2001) [Pubmed]
  17. Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines. Kuo, M.H., Brownell, J.E., Sobel, R.E., Ranalli, T.A., Cook, R.G., Edmondson, D.G., Roth, S.Y., Allis, C.D. Nature (1996) [Pubmed]
  18. Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development. Chi, T.H., Wan, M., Lee, P.P., Akashi, K., Metzger, D., Chambon, P., Wilson, C.B., Crabtree, G.R. Immunity (2003) [Pubmed]
  19. Regulation of skeletal muscle gene expression by p38 MAP kinases. Lluís, F., Perdiguero, E., Nebreda, A.R., Muñoz-Cánoves, P. Trends Cell Biol. (2006) [Pubmed]
  20. Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene. Lee, D.U., Agarwal, S., Rao, A. Immunity (2002) [Pubmed]
  21. FGF2-induced chromatin remodeling regulates CNTF-mediated gene expression and astrocyte differentiation. Song, M.R., Ghosh, A. Nat. Neurosci. (2004) [Pubmed]
  22. Distinct requirements for chromatin assembly in transcriptional repression by thyroid hormone receptor and histone deacetylase. Wong, J., Patterton, D., Imhof, A., Guschin, D., Shi, Y.B., Wolffe, A.P. EMBO J. (1998) [Pubmed]
  23. An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin. Collins, N., Poot, R.A., Kukimoto, I., García-Jiménez, C., Dellaire, G., Varga-Weisz, P.D. Nat. Genet. (2002) [Pubmed]
  24. Active remodeling of somatic nuclei in egg cytoplasm by the nucleosomal ATPase ISWI. Kikyo, N., Wade, P.A., Guschin, D., Ge, H., Wolffe, A.P. Science (2000) [Pubmed]
  25. Cloning of nucleoplasmin from Xenopus laevis oocytes and analysis of its developmental expression. Bürglin, T.R., Mattaj, I.W., Newmeyer, D.D., Zeller, R., De Robertis, E.M. Genes Dev. (1987) [Pubmed]
  26. Inorganic pyrophosphatase is a component of the Drosophila nucleosome remodeling factor complex. Gdula, D.A., Sandaltzopoulos, R., Tsukiyama, T., Ossipow, V., Wu, C. Genes Dev. (1998) [Pubmed]
  27. Combinatorial analysis of transcription factor partners reveals recruitment of c-MYC to estrogen receptor-alpha responsive promoters. Cheng, A.S., Jin, V.X., Fan, M., Smith, L.T., Liyanarachchi, S., Yan, P.S., Leu, Y.W., Chan, M.W., Plass, C., Nephew, K.P., Davuluri, R.V., Huang, T.H. Mol. Cell (2006) [Pubmed]
  28. RNA polymerase II holoenzyme recruitment is sufficient to remodel chromatin at the yeast PHO5 promoter. Gaudreau, L., Schmid, A., Blaschke, D., Ptashne, M., Hörz, W. Cell (1997) [Pubmed]
  29. Isw1 chromatin remodeling ATPase coordinates transcription elongation and termination by RNA polymerase II. Morillon, A., Karabetsou, N., O'Sullivan, J., Kent, N., Proudfoot, N., Mellor, J. Cell (2003) [Pubmed]
  30. BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer. Bochar, D.A., Wang, L., Beniya, H., Kinev, A., Xue, Y., Lane, W.S., Wang, W., Kashanchi, F., Shiekhattar, R. Cell (2000) [Pubmed]
  31. The yeast SAS (something about silencing) protein complex contains a MYST-type putative acetyltransferase and functions with chromatin assembly factor ASF1. Osada, S., Sutton, A., Muster, N., Brown, C.E., Yates, J.R., Sternglanz, R., Workman, J.L. Genes Dev. (2001) [Pubmed]
  32. Dissection of progesterone receptor-mediated chromatin remodeling and transcriptional activation in vivo. Mymryk, J.S., Archer, T.K. Genes Dev. (1995) [Pubmed]
  33. High-frequency gene targeting in Arabidopsis plants expressing the yeast RAD54 gene. Shaked, H., Melamed-Bessudo, C., Levy, A.A. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  34. Proliferation-associated SNF2-like gene (PASG): a SNF2 family member altered in leukemia. Lee, D.W., Zhang, K., Ning, Z.Q., Raabe, E.H., Tintner, S., Wieland, R., Wilkins, B.J., Kim, J.M., Blough, R.I., Arceci, R.J. Cancer Res. (2000) [Pubmed]
  35. STAT4 is required for interleukin-12-induced chromatin remodeling of the CD25 locus. O'Sullivan, A., Chang, H.C., Yu, Q., Kaplan, M.H. J. Biol. Chem. (2004) [Pubmed]
  36. Accumulation of low molecular weight DNA and changes in chromatin structure in HeLa cells treated with human fibroblast interferon. Suhadolnik, R.J., Sawada, Y., Gabriel, J., Reichenbach, N.L., Henderson, E.E. J. Biol. Chem. (1984) [Pubmed]
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