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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

eRF1  -  eukaryotic release factor 1

Drosophila melanogaster

Synonyms: CG5605, Dm0184, Dmel\CG5605, Eukaryotic peptide chain release factor subunit 1, Eukaryotic release factor 1, ...
 
 
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High impact information on eRF1

  • These groups include mutations in the genes encoding the translation factors eRF1 and eIF1A and the kinesin-like protein Pavarotti [1].
  • Thus the eRF1 and eRF3 mutations provide a tool for identifying nonsense alleles that are leaky [2].
 

Anatomical context of eRF1

  • In a screen for suppressors of the Drosophila wingless(PE4) nonsense allele, we isolated mutations in the two components that form eukaryotic release factor. eRF1 and eRF3 comprise the translation termination complex that recognizes stop codons and catalyzes the release of nascent polypeptide chains from ribosomes [2].
 

Associations of eRF1 with chemical compounds

  • We suspect that the context of the stop codon is significant: nonsense alleles sensitive to suppression by eRF1 and eRF3 encode stop codons that are immediately followed by a cytidine [2].

References

  1. A genetic screen in Drosophila for identifying novel components of the hedgehog signaling pathway. Collins, R.T., Cohen, S.M. Genetics (2005) [Pubmed]
  2. Mutations in eukaryotic release factors 1 and 3 act as general nonsense suppressors in Drosophila. Chao, A.T., Dierick, H.A., Addy, T.M., Bejsovec, A. Genetics (2003) [Pubmed]
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