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Gene Review

Klp61F  -  Kinesin-like protein at 61F

Drosophila melanogaster

Synonyms: 6345, Bipolar kinesin KRP-130, CG9191, CG9191-PA, DmKLP61F, ...
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Psychiatry related information on Klp61F


High impact information on Klp61F

  • The complex includes the products of at least three genes: fused (a protein-serine/threonine kinase), cubitus interruptus (a transcription factor), and costal2 (a kinesin-like protein) [2].
  • Genetic analyses indicate that transmission of the Drosophila minichromosome Dp1187 is sensitive to the dosage of nod+, a kinesin-like gene required for the meiotic transmission of achiasmate chromosomes [3].
  • The Drosophila no distributive disjunction (nod) gene encodes a kinesin-like protein that has been proposed to push chromosomes toward the metaphase plate during female meiosis [4].
  • Finally, the clone we isolated appears to correspond to the non-claret disjunctional (ncd) gene, which when mutant causes defects in meiotic and early embryonic mitotic chromosome segregation, and whose recently determined sequence predicts a kinesin-like domain [5].
  • Analyses of this new sequence suggest that the maximal motor unit in the kinesin superfamily may be as little as 350 amino acids, and that the existence of both kinesin and kinesin-like molecules must be an evolutionarily ancient feature of eukaryotes [5].

Biological context of Klp61F


Anatomical context of Klp61F

  • Specifically, our findings suggest that dynein acts to move the poles apart throughout mitosis and that this activity is augmented by KLP61F after the fenestration of the nuclear envelope, a process analogous to nuclear envelope breakdown, which occurs at the onset of prometaphase [10].
  • These antibodies were found to recognize kinesin in rat brain extracts as well as kinesin-like polypeptides in extracts of human neutrophils [11].
  • These observations suggest that KLP61F is bifunctional in germ cells, with microtubule-dependent functions in spindle assembly and microtubule-independent functions in fusome organization [12].
  • In addition, we have used an affinity-purified, KLP61F-specific antiserum to localize native KLP61F and an epitope-tagged KLP61F fusion protein during various stages of mitosis in Drosophila syncytial blastoderm embryos [1].
  • These KRPs cosedimented with microtubules (MTs) polymerized from cytosol treated with AMP-PNP (adenyl-5'-yl imidodiphosphate), and one of them, KRP130, was further purified from ATP eluates of the embryonic MTs [13].

Enzymatic interactions of Klp61F


Regulatory relationships of Klp61F


Other interactions of Klp61F


Analytical, diagnostic and therapeutic context of Klp61F


  1. Motor activity and mitotic spindle localization of the Drosophila kinesin-like protein KLP61F. Barton, N.R., Pereira, A.J., Goldstein, L.S. Mol. Biol. Cell (1995) [Pubmed]
  2. Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2. Robbins, D.J., Nybakken, K.E., Kobayashi, R., Sisson, J.C., Bishop, J.M., Thérond, P.P. Cell (1997) [Pubmed]
  3. Interactions between the nod+ kinesin-like gene and extracentromeric sequences are required for transmission of a Drosophila minichromosome. Murphy, T.D., Karpen, G.H. Cell (1995) [Pubmed]
  4. DNA binding and meiotic chromosomal localization of the Drosophila nod kinesin-like protein. Afshar, K., Barton, N.R., Hawley, R.S., Goldstein, L.S. Cell (1995) [Pubmed]
  5. Identification and characterization of a gene encoding a kinesin-like protein in Drosophila. McDonald, H.B., Goldstein, L.S. Cell (1990) [Pubmed]
  6. Cell cycle-dependent dynamics and regulation of mitotic kinesins in Drosophila S2 cells. Goshima, G., Vale, R.D. Mol. Biol. Cell (2005) [Pubmed]
  7. Novel nuclear defects in KLP61F-deficient mutants in Drosophila are partially suppressed by loss of Ncd function. Wilson, P.G., Simmons, R., Saighal, S., Shigali, S. J. Cell. Sci. (2004) [Pubmed]
  8. Anastral meiotic spindle morphogenesis: role of the non-claret disjunctional kinesin-like protein. Matthies, H.J., McDonald, H.B., Goldstein, L.S., Theurkauf, W.E. J. Cell Biol. (1996) [Pubmed]
  9. Antagonistic microtubule-sliding motors position mitotic centrosomes in Drosophila early embryos. Sharp, D.J., Yu, K.R., Sisson, J.C., Sullivan, W., Scholey, J.M. Nat. Cell Biol. (1999) [Pubmed]
  10. Functional coordination of three mitotic motors in Drosophila embryos. Sharp, D.J., Brown, H.M., Kwon, M., Rogers, G.C., Holland, G., Scholey, J.M. Mol. Biol. Cell (2000) [Pubmed]
  11. Affinity purification and subcellular localization of kinesin in human neutrophils. Rothwell, S.W., Deal, C.C., Pinto, J., Wright, D.G. J. Leukoc. Biol. (1993) [Pubmed]
  12. BimC motor protein KLP61F cycles between mitotic spindles and fusomes in Drosophila germ cells. Wilson, P.G. Curr. Biol. (1999) [Pubmed]
  13. A "slow" homotetrameric kinesin-related motor protein purified from Drosophila embryos. Cole, D.G., Saxton, W.M., Sheehan, K.B., Scholey, J.M. J. Biol. Chem. (1994) [Pubmed]
  14. Hedgehog signal transduction: recent findings. Nybakken, K., Perrimon, N. Curr. Opin. Genet. Dev. (2002) [Pubmed]
  15. A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo. Tay, S.Y., Ingham, P.W., Roy, S. Development (2005) [Pubmed]
  16. Characterization of the KLP68D kinesin-like protein in Drosophila: possible roles in axonal transport. Pesavento, P.A., Stewart, R.J., Goldstein, L.S. J. Cell Biol. (1994) [Pubmed]
  17. The Drosophila meiotic mutant mei-352 is an allele of klp3A and reveals a role for a kinesin-like protein in crossover distribution. Page, S.L., Hawley, R.S. Genetics (2005) [Pubmed]
  18. subito encodes a kinesin-like protein required for meiotic spindle pole formation in Drosophila melanogaster. Giunta, K.L., Jang, J.K., Manheim, E.A., Subramanian, G., McKim, K.S. Genetics (2002) [Pubmed]
  19. Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation. Adams, R.R., Maiato, H., Earnshaw, W.C., Carmena, M. J. Cell Biol. (2001) [Pubmed]
  20. Hedgehog-stimulated phosphorylation of the kinesin-related protein Costal2 is mediated by the serine/threonine kinase fused. Nybakken, K.E., Turck, C.W., Robbins, D.J., Bishop, J.M. J. Biol. Chem. (2002) [Pubmed]
  21. The bipolar kinesin, KLP61F, cross-links microtubules within interpolar microtubule bundles of Drosophila embryonic mitotic spindles. Sharp, D.J., McDonald, K.L., Brown, H.M., Matthies, H.J., Walczak, C., Vale, R.D., Mitchison, T.J., Scholey, J.M. J. Cell Biol. (1999) [Pubmed]
  22. Suppression of the bimC4 mitotic spindle defect by deletion of klpA, a gene encoding a KAR3-related kinesin-like protein in Aspergillus nidulans. O'Connell, M.J., Meluh, P.B., Rose, M.D., Morris, N.R. J. Cell Biol. (1993) [Pubmed]
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