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Chemical Compound Review

cytidine     4-amino-1-[(2R,3R,4S,5R)-3,4- dihydroxy-5...

Synonyms: Cytidin, Zytidin, CP-C, beta.-D-Ribo-C, Posilent (TN), ...
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Disease relevance of Cytosine riboside


Psychiatry related information on Cytosine riboside


High impact information on Cytosine riboside


Chemical compound and disease context of Cytosine riboside


Biological context of Cytosine riboside

  • G:U mismatches resulting from deamination of cytosine are the most common promutagenic lesions occurring in DNA [20].
  • The crystal structure of HaeIII methyltransferase convalently complexed to DNA: an extrahelical cytosine and rearranged base pairing [21].
  • Cellular differentiation, cytidine analogs and DNA methylation [22].
  • Nucleotide sequence analysis of cloned DNA and electrophoretic analysis of appropriate small fragments from animal tissue reveal a population of length polymorphs containing from nine to 19 cytosine residues [23].
  • We have solved the crystal structure of an all-RNA hammerhead ribozyme having a single 2'-O-methyl cytosine incorporated at the active site to prevent cleavage [24].

Anatomical context of Cytosine riboside


Associations of Cytosine riboside with other chemical compounds

  • Analysis of the norepinephrine-transporter gene revealed that the proband was heterozygous for a mutation in exon 9 (encoding a change from guanine to cytosine at position 237) that resulted in more than a 98 percent loss of function as compared with that of the wild-type gene [30].
  • A cytidine phosphate guanosine dinucleotide C-to-T point mutation in intron 19 of the CFTR gene, termed 3849 + 10 kb C to T, was identified in 13 patients from eight unrelated families [31].
  • 5-Azacytidine is a cytidine analogue that is capable of activating repressed genes in tissue-culture cells and has been shown to increase hemoglobin-F production in anemic baboons [32].
  • They also suggest that the occurrence of mutational hot spots at CpG sites may not always be due to spontaneous deamination of 5-methylcytosine, but might also be initiated by enzymatic deamination of cytosine and proceed through a C-->U-->T pathway [33].
  • Mutations responsible for this phenotype have been identified in 23 independent strains selected for resistance to arabinosyl cytosine and 5-fluorouracil [34].

Gene context of Cytosine riboside


Analytical, diagnostic and therapeutic context of Cytosine riboside


  1. Bacteriophage T4 Alc protein: a transcription termination factor sensing local modification of DNA. Kashlev, M., Nudler, E., Goldfarb, A., White, T., Kutter, E. Cell (1993) [Pubmed]
  2. Transcription of IAP endogenous retroviruses is constrained by cytosine methylation. Walsh, C.P., Chaillet, J.R., Bestor, T.H. Nat. Genet. (1998) [Pubmed]
  3. Transcription-associated mutational asymmetry in mammalian evolution. Green, P., Ewing, B., Miller, W., Thomas, P.J., Green, E.D. Nat. Genet. (2003) [Pubmed]
  4. The vsr gene product of E. coli K-12 is a strand- and sequence-specific DNA mismatch endonuclease. Hennecke, F., Kolmar, H., Bründl, K., Fritz, H.J. Nature (1991) [Pubmed]
  5. Viral vector transduction of the human deoxycytidine kinase cDNA sensitizes glioma cells to the cytotoxic effects of cytosine arabinoside in vitro and in vivo. Manome, Y., Wen, P.Y., Dong, Y., Tanaka, T., Mitchell, B.S., Kufe, D.W., Fine, H.A. Nat. Med. (1996) [Pubmed]
  6. DNA cytosine methylation in brain of patients with Alzheimer's disease. Schwob, N.G., Nalbantoglu, J., Hastings, K.E., Mikkelsen, T., Cashman, N.R. Ann. Neurol. (1990) [Pubmed]
  7. APOBEC3 proteins inhibit human LINE-1 retrotransposition. Muckenfuss, H., Hamdorf, M., Held, U., Perkovic, M., Löwer, J., Cichutek, K., Flory, E., Schumann, G.G., Münk, C. J. Biol. Chem. (2006) [Pubmed]
  8. Antidepressant-like effects of cytidine in the forced swim test in rats. Carlezon, W.A., Pliakas, A.M., Parow, A.M., Detke, M.J., Cohen, B.M., Renshaw, P.F. Biol. Psychiatry (2002) [Pubmed]
  9. Maternal care associated with methylation of the estrogen receptor-alpha1b promoter and estrogen receptor-alpha expression in the medial preoptic area of female offspring. Champagne, F.A., Weaver, I.C., Diorio, J., Dymov, S., Szyf, M., Meaney, M.J. Endocrinology (2006) [Pubmed]
  10. Eukaryotic cytosine methyltransferases. Goll, M.G., Bestor, T.H. Annu. Rev. Biochem. (2005) [Pubmed]
  11. The biochemistry of mutagenesis. Drake, J.W., Baltz, R.H. Annu. Rev. Biochem. (1976) [Pubmed]
  12. Dissecting Arabidopsis thaliana DICER function in small RNA processing, gene silencing and DNA methylation patterning. Henderson, I.R., Zhang, X., Lu, C., Johnson, L., Meyers, B.C., Green, P.J., Jacobsen, S.E. Nat. Genet. (2006) [Pubmed]
  13. Plant nuclear RNA polymerase IV mediates siRNA and DNA methylation-dependent heterochromatin formation. Onodera, Y., Haag, J.R., Ream, T., Nunes, P.C., Pontes, O., Pikaard, C.S. Cell (2005) [Pubmed]
  14. Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation. Ting, A.H., Schuebel, K.E., Herman, J.G., Baylin, S.B. Nat. Genet. (2005) [Pubmed]
  15. 'Pseudo' domains in phage-encoded DNA methyltransferases. Lange, C., Jugel, A., Walter, J., Noyer-Weidner, M., Trautner, T.A. Nature (1991) [Pubmed]
  16. Differential competition with cytotoxic agents: an approach to selectivity in cancer chemotherapy. Rabinowitz, M., Uehara, Y., Vistica, D.T. Science (1979) [Pubmed]
  17. Rhodamine-123 selectively reduces clonal growth of carcinoma cells in vitro. Bernal, S.D., Lampidis, T.J., Summerhayes, I.C., Chen, L.B. Science (1982) [Pubmed]
  18. Cellular quantitation of in vivo effects of 1-beta-D-arabinofuranosylcytosine on leukemia L1210. Edelstein, M., Valeriote, F., Vietti, T. J. Natl. Cancer Inst. (1977) [Pubmed]
  19. Molecular genetic evidence of bacterial colonization of cholesterol gallstones. Swidsinski, A., Ludwig, W., Pahlig, H., Priem, F. Gastroenterology (1995) [Pubmed]
  20. Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions. Barrett, T.E., Savva, R., Panayotou, G., Barlow, T., Brown, T., Jiricny, J., Pearl, L.H. Cell (1998) [Pubmed]
  21. The crystal structure of HaeIII methyltransferase convalently complexed to DNA: an extrahelical cytosine and rearranged base pairing. Reinisch, K.M., Chen, L., Verdine, G.L., Lipscomb, W.N. Cell (1995) [Pubmed]
  22. Cellular differentiation, cytidine analogs and DNA methylation. Jones, P.A., Taylor, S.M. Cell (1980) [Pubmed]
  23. Heterogeneous mitochondrial DNA D-loop sequences in bovine tissue. Hauswirth, W.W., Van de Walle, M.J., Laipis, P.J., Olivo, P.D. Cell (1984) [Pubmed]
  24. The crystal structure of an all-RNA hammerhead ribozyme: a proposed mechanism for RNA catalytic cleavage. Scott, W.G., Finch, J.T., Klug, A. Cell (1995) [Pubmed]
  25. Reprogramming cell differentiation in the absence of DNA synthesis. Chiu, C.P., Blau, H.M. Cell (1984) [Pubmed]
  26. RNA editing by cytidine insertion in mitochondria of Physarum polycephalum. Mahendran, R., Spottswood, M.R., Miller, D.L. Nature (1991) [Pubmed]
  27. Myelination of central nervous system axons in tissue culture by transplanted oligodendrocytes. Seil, F., Blank, N.K. Science (1981) [Pubmed]
  28. 5-Methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes. Rideout, W.M., Coetzee, G.A., Olumi, A.F., Jones, P.A. Science (1990) [Pubmed]
  29. Retinoic acid stimulates regeneration of mammalian auditory hair cells. Lefebvre, P.P., Malgrange, B., Staecker, H., Moonen, G., Van de Water, T.R. Science (1993) [Pubmed]
  30. Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency. Shannon, J.R., Flattem, N.L., Jordan, J., Jacob, G., Black, B.K., Biaggioni, I., Blakely, R.D., Robertson, D. N. Engl. J. Med. (2000) [Pubmed]
  31. A novel mutation in the cystic fibrosis gene in patients with pulmonary disease but normal sweat chloride concentrations. Highsmith, W.E., Burch, L.H., Zhou, Z., Olsen, J.C., Boat, T.E., Spock, A., Gorvoy, J.D., Quittel, L., Friedman, K.J., Silverman, L.M. N. Engl. J. Med. (1994) [Pubmed]
  32. 5-azacytidine selectively increases gamma-globin synthesis in a patient with beta+ thalassemia. Ley, T.J., DeSimone, J., Anagnou, N.P., Keller, G.H., Humphries, R.K., Turner, P.H., Young, N.S., Keller, P., Nienhuis, A.W. N. Engl. J. Med. (1982) [Pubmed]
  33. High frequency mutagenesis by a DNA methyltransferase. Shen, J.C., Rideout, W.M., Jones, P.A. Cell (1992) [Pubmed]
  34. Clustered base substitutions in CTP synthetase conferring drug resistance in Chinese hamster ovary cells. Whelan, J., Phear, G., Yamauchi, M., Meuth, M. Nat. Genet. (1993) [Pubmed]
  35. DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Fuks, F., Burgers, W.A., Brehm, A., Hughes-Davies, L., Kouzarides, T. Nat. Genet. (2000) [Pubmed]
  36. Acetylated histones are associated with FMR1 in normal but not fragile X-syndrome cells. Coffee, B., Zhang, F., Warren, S.T., Reines, D. Nat. Genet. (1999) [Pubmed]
  37. Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase. Jackson, J.P., Lindroth, A.M., Cao, X., Jacobsen, S.E. Nature (2002) [Pubmed]
  38. Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylation. Lindroth, A.M., Cao, X., Jackson, J.P., Zilberman, D., McCallum, C.M., Henikoff, S., Jacobsen, S.E. Science (2001) [Pubmed]
  39. Erasure of histone acetylation by Arabidopsis HDA6 mediates large-scale gene silencing in nucleolar dominance. Earley, K., Lawrence, R.J., Pontes, O., Reuther, R., Enciso, A.J., Silva, M., Neves, N., Gross, M., Viegas, W., Pikaard, C.S. Genes Dev. (2006) [Pubmed]
  40. Extensive methylation of chloroplast DNA by a nuclear gene mutation does not affect chloroplast gene transmission in chlamydomonas. Bolen, P.L., Grant, D.M., Swinton, D., Boynton, J.E., Gillham, N.W. Cell (1982) [Pubmed]
  41. Tumoricidal response induced by cytosine arabinoside after plasma perfusion over protein A. Terman, D.S., Yamamoto, T., Tillquist, R.L., Henry, J.F., Cook, G.L., Silvers, A., Shearer, W.T. Science (1980) [Pubmed]
  42. Cytidine 3',5'-monophosphate phosphodiesterase: decreased activity in the regenerating and developing liver. Shoji, M., Brackett, N.L., Kuo, J.F. Science (1978) [Pubmed]
  43. In vivo footprint and methylation analysis by PCR-aided genomic sequencing: comparison of active and inactive X chromosomal DNA at the CpG island and promoter of human PGK-1. Pfeifer, G.P., Tanguay, R.L., Steigerwald, S.D., Riggs, A.D. Genes Dev. (1990) [Pubmed]
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