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Chemical Compound Review

cytidine     4-amino-1-[(2R,3R,4S,5R)-3,4- dihydroxy-5...

Synonyms: Cytidin, Zytidin, CP-C, beta.-D-Ribo-C, Posilent (TN), ...
 
 
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Disease relevance of Cytosine riboside

 

Psychiatry related information on Cytosine riboside

 

High impact information on Cytosine riboside

 

Chemical compound and disease context of Cytosine riboside

 

Biological context of Cytosine riboside

  • G:U mismatches resulting from deamination of cytosine are the most common promutagenic lesions occurring in DNA [20].
  • The crystal structure of HaeIII methyltransferase convalently complexed to DNA: an extrahelical cytosine and rearranged base pairing [21].
  • Cellular differentiation, cytidine analogs and DNA methylation [22].
  • Nucleotide sequence analysis of cloned DNA and electrophoretic analysis of appropriate small fragments from animal tissue reveal a population of length polymorphs containing from nine to 19 cytosine residues [23].
  • We have solved the crystal structure of an all-RNA hammerhead ribozyme having a single 2'-O-methyl cytosine incorporated at the active site to prevent cleavage [24].
 

Anatomical context of Cytosine riboside

 

Associations of Cytosine riboside with other chemical compounds

  • Analysis of the norepinephrine-transporter gene revealed that the proband was heterozygous for a mutation in exon 9 (encoding a change from guanine to cytosine at position 237) that resulted in more than a 98 percent loss of function as compared with that of the wild-type gene [30].
  • A cytidine phosphate guanosine dinucleotide C-to-T point mutation in intron 19 of the CFTR gene, termed 3849 + 10 kb C to T, was identified in 13 patients from eight unrelated families [31].
  • 5-Azacytidine is a cytidine analogue that is capable of activating repressed genes in tissue-culture cells and has been shown to increase hemoglobin-F production in anemic baboons [32].
  • They also suggest that the occurrence of mutational hot spots at CpG sites may not always be due to spontaneous deamination of 5-methylcytosine, but might also be initiated by enzymatic deamination of cytosine and proceed through a C-->U-->T pathway [33].
  • Mutations responsible for this phenotype have been identified in 23 independent strains selected for resistance to arabinosyl cytosine and 5-fluorouracil [34].
 

Gene context of Cytosine riboside

 

Analytical, diagnostic and therapeutic context of Cytosine riboside

References

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