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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

irx1a  -  iroquois homeobox 1a

Danio rerio

Synonyms: SO:0000704, irx1, zgc:109702, zgc:136490, ziro1, ...
 
 
 
 
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High impact information on irx1a

  • Here, we show that the zebrafish Iroquois homolog irx1a is expressed during retinogenesis and knockdown of irx1a results in a retinal phenotype strikingly similar to those of sonic hedgehog (shh) mutants [1].
  • Analysis of shh-GFP transgene expression in irx1a knockdown retinas revealed that irx1a is required for the propagation of shh expression through the retina [1].
 

Analytical, diagnostic and therapeutic context of irx1a

  • Transplantation experiments illustrated that the effects of irx1a on shh expression are both cell-autonomous and non-cell-autonomous [1].

References

  1. The homeobox gene irx1a is required for the propagation of the neurogenic waves in the zebrafish retina. Cheng, C.W., Yan, C.H., Hui, C.C., Strähle, U., Cheng, S.H. Mech. Dev. (2006) [Pubmed]
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