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Gene Review

irx1a  -  iroquois homeobox 1a

Danio rerio

Synonyms: SO:0000704, irx1, zgc:109702, zgc:136490, ziro1, ...
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High impact information on irx1a

  • Here, we show that the zebrafish Iroquois homolog irx1a is expressed during retinogenesis and knockdown of irx1a results in a retinal phenotype strikingly similar to those of sonic hedgehog (shh) mutants [1].
  • Analysis of shh-GFP transgene expression in irx1a knockdown retinas revealed that irx1a is required for the propagation of shh expression through the retina [1].

Analytical, diagnostic and therapeutic context of irx1a

  • Transplantation experiments illustrated that the effects of irx1a on shh expression are both cell-autonomous and non-cell-autonomous [1].


  1. The homeobox gene irx1a is required for the propagation of the neurogenic waves in the zebrafish retina. Cheng, C.W., Yan, C.H., Hui, C.C., Strähle, U., Cheng, S.H. Mech. Dev. (2006) [Pubmed]
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