MeSH Review:
Transgenes
- Effective treatment of familial hypercholesterolaemia in the mouse model using adenovirus-mediated transfer of the VLDL receptor gene. Kozarsky, K.F., Jooss, K., Donahee, M., Strauss, J.F., Wilson, J.M. Nat. Genet. (1996)
- Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle. Musarò, A., McCullagh, K., Paul, A., Houghton, L., Dobrowolny, G., Molinaro, M., Barton, E.R., Sweeney, H.L., Rosenthal, N. Nat. Genet. (2001)
- Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. Lee, K.F., Li, E., Huber, L.J., Landis, S.C., Sharpe, A.H., Chao, M.V., Jaenisch, R. Cell (1992)
- Expression of the BNLF-1 oncogene of Epstein-Barr virus in the skin of transgenic mice induces hyperplasia and aberrant expression of keratin 6. Wilson, J.B., Weinberg, W., Johnson, R., Yuspa, S., Levine, A.J. Cell (1990)
- Recombinant adeno-associated virus for muscle directed gene therapy. Fisher, K.J., Jooss, K., Alston, J., Yang, Y., Haecker, S.E., High, K., Pathak, R., Raper, S.E., Wilson, J.M. Nat. Med. (1997)
- Molecular cloning of linotte in Drosophila: a novel gene that functions in adults during associative learning. Bolwig, G.M., Del Vecchio, M., Hannon, G., Tully, T. Neuron (1995)
- Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway. Yamamoto, A., Cremona, M.L., Rothman, J.E. J. Cell Biol. (2006)
- Protein tyrosine phosphatase epsilon increases the risk of mammary hyperplasia and mammary tumors in transgenic mice. Elson, A. Oncogene (1999)
- Kinetics of efficient recombinant adeno-associated virus transduction in retinal pigment epithelial cells. Lai, Y.K., Rolling, F., Baker, E., Rakoczy, P.E. Exp. Cell Res. (2001)
- Neurobehavioral characteristics of mice with modified intermediate filament genes. Lalonde, R., Strazielle, C. Reviews in the neurosciences. (2003)
- Mechanism of transcriptional silencing in yeast. Chen, L., Widom, J. Cell (2005)
- MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Mansfield, J.H., Harfe, B.D., Nissen, R., Obenauer, J., Srineel, J., Chaudhuri, A., Farzan-Kashani, R., Zuker, M., Pasquinelli, A.E., Ruvkun, G., Sharp, P.A., Tabin, C.J., McManus, M.T. Nat. Genet. (2004)
- Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia. Pollock, P.M., Cohen-Solal, K., Sood, R., Namkoong, J., Martino, J.J., Koganti, A., Zhu, H., Robbins, C., Makalowska, I., Shin, S.S., Marin, Y., Roberts, K.G., Yudt, L.M., Chen, A., Cheng, J., Incao, A., Pinkett, H.W., Graham, C.L., Dunn, K., Crespo-Carbone, S.M., Mackason, K.R., Ryan, K.B., Sinsimer, D., Goydos, J., Reuhl, K.R., Eckhaus, M., Meltzer, P.S., Pavan, W.J., Trent, J.M., Chen, S. Nat. Genet. (2003)
- Amnionless, essential for mouse gastrulation, is mutated in recessive hereditary megaloblastic anemia. Tanner, S.M., Aminoff, M., Wright, F.A., Liyanarachchi, S., Kuronen, M., Saarinen, A., Massika, O., Mandel, H., Broch, H., de la Chapelle, A. Nat. Genet. (2003)
- Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Chambers, I., Colby, D., Robertson, M., Nichols, J., Lee, S., Tweedie, S., Smith, A. Cell (2003)
- Autoimmune diabetes can be induced in transgenic major histocompatibility complex class II-deficient mice. Laufer, T.M., von Herrath, M.G., Grusby, M.J., Oldstone, M.B., Glimcher, L.H. J. Exp. Med. (1993)
- Pulmonary overexpression of IL-9 induces Th2 cytokine expression, leading to immune pathology. Temann, U.A., Ray, P., Flavell, R.A. J. Clin. Invest. (2002)
- Tumor-specific gene delivery using recombinant vaccinia virus in a rabbit model of liver metastases. Gnant, M.F., Noll, L.A., Irvine, K.R., Puhlmann, M., Terrill, R.E., Alexander, H.R., Bartlett, D.L. J. Natl. Cancer Inst. (1999)
- Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury. Marber, M.S., Mestril, R., Chi, S.H., Sayen, M.R., Yellon, D.M., Dillmann, W.H. J. Clin. Invest. (1995)
- Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation. Waxman, A.B., Einarsson, O., Seres, T., Knickelbein, R.G., Warshaw, J.B., Johnston, R., Homer, R.J., Elias, J.A. J. Clin. Invest. (1998)
- Functional identification of the mouse circadian Clock gene by transgenic BAC rescue. Antoch, M.P., Song, E.J., Chang, A.M., Vitaterna, M.H., Zhao, Y., Wilsbacher, L.D., Sangoram, A.M., King, D.P., Pinto, L.H., Takahashi, J.S. Cell (1997)
- A functional enhancer suppresses silencing of a transgene and prevents its localization close to centrometric heterochromatin. Francastel, C., Walters, M.C., Groudine, M., Martin, D.I. Cell (1999)
- DNA methylation represses transcription in vivo. Siegfried, Z., Eden, S., Mendelsohn, M., Feng, X., Tsuberi, B.Z., Cedar, H. Nat. Genet. (1999)
- Cre-mediated chromosome loss in mice. Lewandoski, M., Martin, G.R. Nat. Genet. (1997)
- Variations of cervical vertebrae after expression of a Hox-1.1 transgene in mice. Kessel, M., Balling, R., Gruss, P. Cell (1990)
- Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Akashi, K., Kondo, M., von Freeden-Jeffry, U., Murray, R., Weissman, I.L. Cell (1997)
- Skeletal muscle-specific expression of a utrophin transgene rescues utrophin-dystrophin deficient mice. Rafael, J.A., Tinsley, J.M., Potter, A.C., Deconinck, A.E., Davies, K.E. Nat. Genet. (1998)
- Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system. Lim, K.C., Lakshmanan, G., Crawford, S.E., Gu, Y., Grosveld, F., Engel, J.D. Nat. Genet. (2000)
- Abnormal myotonic dystrophy protein kinase levels produce only mild myopathy in mice. Jansen, G., Groenen, P.J., Bächner, D., Jap, P.H., Coerwinkel, M., Oerlemans, F., van den Broek, W., Gohlsch, B., Pette, D., Plomp, J.J., Molenaar, P.C., Nederhoff, M.G., van Echteld, C.J., Dekker, M., Berns, A., Hameister, H., Wieringa, B. Nat. Genet. (1996)
- Myelin deficient mice: expression of myelin basic protein and generation of mice with varying levels of myelin. Popko, B., Puckett, C., Lai, E., Shine, H.D., Readhead, C., Takahashi, N., Hunt, S.W., Sidman, R.L., Hood, L. Cell (1987)
- The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice. LaFerla, F.M., Tinkle, B.T., Bieberich, C.J., Haudenschild, C.C., Jay, G. Nat. Genet. (1995)
- Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression. Wang, J., Wilhelmsson, H., Graff, C., Li, H., Oldfors, A., Rustin, P., Brüning, J.C., Kahn, C.R., Clayton, D.A., Barsh, G.S., Thorén, P., Larsson, N.G. Nat. Genet. (1999)
- Affinity maturation leads to differential expression of multiple copies of a kappa light-chain transgene. Lozano, F., Rada, C., Jarvis, J.M., Milstein, C. Nature (1993)
- Superweed study falters as seed firms deny access to transgene. Dalton, R., Diego, S. Nature (2002)
- Control of memory formation through regulated expression of a CaMKII transgene. Mayford, M., Bach, M.E., Huang, Y.Y., Wang, L., Hawkins, R.D., Kandel, E.R. Science (1996)
- A 450 kb transgene displays properties of the mammalian X-inactivation center. Lee, J.T., Strauss, W.M., Dausman, J.A., Jaenisch, R. Cell (1996)
- BRCA1 supports XIST RNA concentration on the inactive X chromosome. Ganesan, S., Silver, D.P., Greenberg, R.A., Avni, D., Drapkin, R., Miron, A., Mok, S.C., Randrianarison, V., Brodie, S., Salstrom, J., Rasmussen, T.P., Klimke, A., Marrese, C., Marahrens, Y., Deng, C.X., Feunteun, J., Livingston, D.M. Cell (2002)
- The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis. Sternlicht, M.D., Lochter, A., Sympson, C.J., Huey, B., Rougier, J.P., Gray, J.W., Pinkel, D., Bissell, M.J., Werb, Z. Cell (1999)
- Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis. Cormier, R.T., Hong, K.H., Halberg, R.B., Hawkins, T.L., Richardson, P., Mulherkar, R., Dove, W.F., Lander, E.S. Nat. Genet. (1997)
- A counterdefensive strategy of plant viruses: suppression of posttranscriptional gene silencing. Kasschau, K.D., Carrington, J.C. Cell (1998)
- Overexpression of dystrophin in transgenic mdx mice eliminates dystrophic symptoms without toxicity. Cox, G.A., Cole, N.M., Matsumura, K., Phelps, S.F., Hauschka, S.D., Campbell, K.P., Faulkner, J.A., Chamberlain, J.S. Nature (1993)
- Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors. Miyoshi, H., Smith, K.A., Mosier, D.E., Verma, I.M., Torbett, B.E. Science (1999)
- Genetic regulation of glutamate receptor ion channels. Myers, S.J., Dingledine, R., Borges, K. Annu. Rev. Pharmacol. Toxicol. (1999)
- legless insertional mutation: morphological, molecular, and genetic characterization. Singh, G., Supp, D.M., Schreiner, C., McNeish, J., Merker, H.J., Copeland, N.G., Jenkins, N.A., Potter, S.S., Scott, W. Genes Dev. (1991)