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Gene Review

COL4A1  -  collagen, type IV, alpha 1

Canis lupus familiaris

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Disease relevance of COL4A1

  • Increased expression of COL4A1 and TIMP-1 at the end stage of disease supports the suggestion that expression increases in association with progression of fibrosis and confirms an observation of increased COL4A1 protein expression [1].


  1. Gene expression analysis in a canine model of X-linked Alport syndrome. Greer, K.A., Higgins, M.A., Cox, M.L., Ryan, T.P., Berridge, B.R., Kashtan, C.E., Lees, G.E., Murphy, K.E. Mamm. Genome (2006) [Pubmed]
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