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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Fibrosis

 
 
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Disease relevance of Fibrosis

 

Psychiatry related information on Fibrosis

 

High impact information on Fibrosis

  • Ankylosing spondylitis with fibrosis and carcinoma of the lung [12].
  • Hereditary hemochromatosis is a prevalent genetic disorder of iron hyperabsorption leading to hyperferremia, tissue iron deposition and complications including cirrhosis, hepatocarcinoma, cardiomyopathy and diabetes [13].
  • Heterozygous mutations of the kinesin KIF21A in congenital fibrosis of the extraocular muscles type 1 (CFEOM1) [14].
  • We describe mutations in NPHP3 in families with isolated NPHP and in families with NPHP with associated hepatic fibrosis or tapeto-retinal degeneration [15].
  • Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis [15].
 

Chemical compound and disease context of Fibrosis

  • Gastrointestinal bleeding after abrupt cessation of propranolol administration in cirrhosis [16].
  • Decreased serum HDL3, cholesterol levels in cirrhosis of the liver [17].
  • All patients who had received cyclosporine had interstitial fibrosis, tubular atrophy, or both [18].
  • In a study of 26 patients with cirrhosis, plasma norepinephrine concentrations were significantly higher in 19 patients who abnormally excreted an acute water load than in seven who excreted the load normally (8324 +/- 116 vs. 306 +/- 33 pg per milliliter; P less than 0.001) [19].
  • METHODS: In a double-blind, prospective trial, 199 patients with cirrhosis and acute variceal bleeding who underwent emergency sclerotherapy were randomly assigned to receive a continuous infusion of octreotide (25 micrograms per hour) or placebo for five days [20].
  • In bleomycin-induced fibrosis in mice, TSA prevented dermal accumulation of extracellular matrix in vivo [21].
  • There were statistically significant but weak correlations of fibrosis with platelet count, albumin, bilirubin, INR, and hyaluronic acid; however, changes in these did not correlate with or predict changes in fibrosis in the liver biopsy [22].
  • Calcium is natriuretic in patients with preascitic cirrhosis; it also decreases norepinephrine release, which could be responsible for decreased reabsorption of sodium in the Henle's loop [23].
  • Hepatic steatosis, injury, fibrosis, markers of lipid peroxidation/oxidant stress, and systemic insulin sensitivity were evaluated [24].
  • In the model of preestablished dermal fibrosis, imatinib not only stopped further progression of fibrosis but also induced regression of preexisting dermal fibrosis, with a reduction in dermal thickness below pretreatment levels [25].
  • In a further experiment, insulin treatment protected against fibrosis and CRP increases in HFD+DM, showing that diabetes, not streptozotocin, causes the fibrosis [26].
 

Biological context of Fibrosis

 

Anatomical context of Fibrosis

 

Gene context of Fibrosis

  • We have previously described a mutation in the keratin 18 gene in a patient with cryptogenic cirrhosis, but the importance of mutations in the keratin 8 and keratin 18 genes in such patients is unclear [36].
  • IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis [37].
  • In response to external stress, Klf5(+/-) mice showed diminished levels of arterial-wall thickening, angiogenesis, cardiac hypertrophy and interstitial fibrosis [38].
  • In contrast, FGF-6(-/-) mutant mice show a severe regeneration defect with fibrosis and myotube degeneration [39].
  • Fibrosis increased despite the fact that IL-13 levels decreased significantly in the liver and serum [40].
  • We show that local and transient TGF-beta1 overexpression induces homogenous, prolonged, and progressive pleural fibrosis without pleurodesis, associated with severe impairment of pulmonary function [41].
 

Analytical, diagnostic and therapeutic context of Fibrosis

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