Gene Review:
TIMP1 - TIMP metallopeptidase inhibitor 1
Homo sapiens
Synonyms:
CLGI, Collagenase inhibitor, EPA, EPO, Erythroid-potentiating activity, ...
McKaig,
Solini,
Rassidakis,
Fujio,
Kapaki,
Bieber,
Medeiros,
Amin,
Soini,
Papassotiropoulos,
Santini,
Grimaldi,
Bosshardt,
de Quervain,
Henke,
Autio-Harmainen,
Umbricht,
Ramdas,
Watson,
Hock,
Nitsch,
Mahida,
Nannipieri,
Hegi,
Wollmer,
Lai,
Streffer,
McWilliams,
Ferrannini,
Maddalena,
Pasch,
Degonda,
Lemke,
Satta,
Jung,
Kunisada,
Cutler,
Salani,
Paraskevas,
Gilles,
Goy,
Määttä,
- Signal transducer and activator of transcription-3 activation contributes to high tissue inhibitor of metalloproteinase-1 expression in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. Lai, R., Rassidakis, G.Z., Medeiros, L.J., Ramdas, L., Goy, A.H., Cutler, C., Fujio, Y., Kunisada, K., Amin, H.M., Gilles, F. Am. J. Pathol. (2004)
- Expression profiling of microdissected pancreatic adenocarcinomas. Crnogorac-Jurcevic, T., Efthimiou, E., Nielsen, T., Loader, J., Terris, B., Stamp, G., Baron, A., Scarpa, A., Lemoine, N.R. Oncogene (2002)
- TIMP1 and adverse prognosis in non-small cell lung cancer. Fong, K.M., Kida, Y., Zimmerman, P.V., Smith, P.J. Clin. Cancer Res. (1996)
- Expression of MMP2, MMP9, MT1-MMP, TIMP1, and TIMP2 mRNA in valvular lesions of the heart. Soini, Y., Satta, J., Määttä, M., Autio-Harmainen, H. J. Pathol. (2001)
- Tissue inhibitors of matrix metalloproteinases are elevated in cerebrospinal fluid of neurodegenerative diseases. Lorenzl, S., Albers, D.S., LeWitt, P.A., Chirichigno, J.W., Hilgenberg, S.L., Cudkowicz, M.E., Beal, M.F. J. Neurol. Sci. (2003)
- Matrix metalloproteinase profile in patients with Creuztfeldt-Jakob disease. Kettlun, A., Collados, L., García, L., Cartier, L.A., Wolf, M.E., Mosnaim, A.D., Valenzuela, M.A. International journal of clinical practice. (2003)
- Stress-related modulation of matrix metalloproteinase expression. Yang, E.V., Bane, C.M., MacCallum, R.C., Kiecolt-Glaser, J.K., Malarkey, W.B., Glaser, R. J. Neuroimmunol. (2002)
- Genetic polymorphisms and cerebrospinal fluid levels of tissue inhibitor of metalloproteinases 1 in sporadic Alzheimer's disease. Wollmer, M.A., Papassotiropoulos, A., Streffer, J.R., Grimaldi, L.M., Kapaki, E., Salani, G., Paraskevas, G.P., Maddalena, A., de Quervain, D., Bieber, C., Umbricht, D., Lemke, U., Bosshardt, S., Degonda, N., Henke, K., Hegi, T., Jung, H.H., Pasch, T., Hock, C., Nitsch, R.M. Psychiatr. Genet. (2002)
- Validation of the holyoake codependency index. Dear, G.E., Roberts, C.M. The Journal of psychology. (2005)
- Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1. Gomis-Rüth, F.X., Maskos, K., Betz, M., Bergner, A., Huber, R., Suzuki, K., Yoshida, N., Nagase, H., Brew, K., Bourenkov, G.P., Bartunik, H., Bode, W. Nature (1997)
- Molecular characterization and expression of the gene encoding human erythroid-potentiating activity. Gasson, J.C., Golde, D.W., Kaufman, S.E., Westbrook, C.A., Hewick, R.M., Kaufman, R.J., Wong, G.G., Temple, P.A., Leary, A.C., Brown, E.L. Nature (1985)
- Epidermal growth factor receptor signaling and the invasive phenotype of ovarian carcinoma cells. Alper O, n.u.l.l., Bergmann-Leitner, E.S., Bennett, T.A., Hacker, N.F., Stromberg, K., Stetler-Stevenson, W.G. J. Natl. Cancer Inst. (2001)
- Biophysical and functional characterization of full-length, recombinant human tissue inhibitor of metalloproteinases-2 (TIMP-2) produced in Escherichia coli. Comparison of wild type and amino-terminal alanine appended variant with implications for the mechanism of TIMP functions. Wingfield, P.T., Sax, J.K., Stahl, S.J., Kaufman, J., Palmer, I., Chung, V., Corcoran, M.L., Kleiner, D.E., Stetler-Stevenson, W.G. J. Biol. Chem. (1999)
- STAT proteins mediate angiotensin II-induced production of TIMP-1 in human proximal tubular epithelial cells. Chen, X., Wang, J., Zhou, F., Wang, X., Feng, Z. Kidney Int. (2003)
- Effects of 17beta-estradiol on the expression of matrix metalloproteinase-1, -2 and tissue inhibitor of metalloproteinase-1 in human osteoblast-like cell cultures. Liao, E.Y., Luo, X.H. Endocrine (2001)
- Effect of tranilast on matrix metalloproteinase production from neutrophils in-vitro. Shimizu, T., Kanai, K., Kyo, Y., Asano, K., Hisamitsu, T., Suzaki, H. J. Pharm. Pharmacol. (2006)
- Dibutyryl cyclic AMP-induced enhancement of tissue inhibitor of metalloproteinases-3 expression and its possible relation to the invasive activity of the human hepatoma cell line PLC/PRF/5. Okamoto, Y., Nakano, H. Anticancer Res. (1999)
- Polymorphic X-chromosome inactivation of the human TIMP1 gene. Anderson, C.L., Brown, C.J. Am. J. Hum. Genet. (1999)
- Variability of X chromosome inactivation: effect on levels of TIMP1 RNA and role of DNA methylation. Anderson, C.L., Brown, C.J. Hum. Genet. (2002)
- Active and tissue inhibitor of matrix metalloproteinase-free gelatinase B accumulates within human microvascular endothelial vesicles. Nguyen, M., Arkell, J., Jackson, C.J. J. Biol. Chem. (1998)
- Imbalance of expression of matrix metalloproteinases (MMPs) and tissue inhibitors of the matrix metalloproteinases (TIMPs) in human pancreatic carcinoma. Bramhall, S.R., Neoptolemos, J.P., Stamp, G.W., Lemoine, N.R. J. Pathol. (1997)
- Rheumatoid synovial endothelial cells secrete decreased levels of tissue inhibitor of MMP (TIMP1). Jackson, C.J., Arkell, J., Nguyen, M. Ann. Rheum. Dis. (1998)
- High glucose and homocysteine synergistically affect the metalloproteinases-tissue inhibitors of metalloproteinases pattern, but not TGFB expression, in human fibroblasts. Solini, A., Santini, E., Nannipieri, M., Ferrannini, E. Diabetologia (2006)
- Regulation of the levels of human trabecular matrix metalloproteinases and inhibitor by interleukin-1 and dexamethasone. Samples, J.R., Alexander, J.P., Acott, T.S. Invest. Ophthalmol. Vis. Sci. (1993)
- Implications of decidualization-associated protease expression in implantation and menstruation. Schatz, F., Krikun, G., Runic, R., Wang, E.Y., Hausknecht, V., Lockwood, C.J. Semin. Reprod. Endocrinol. (1999)
- Impaired migration, integrin function, and actin cytoskeletal organization in dermal fibroblasts from a subset of aged human donors. Reed, M.J., Ferara, N.S., Vernon, R.B. Mech. Ageing Dev. (2001)
- Gonadotropins activate proteolysis and increase invasion through protein kinase A and phosphatidylinositol 3-kinase pathways in human epithelial ovarian cancer cells. Choi, J.H., Choi, K.C., Auersperg, N., Leung, P.C. Cancer Res. (2006)
- Myeloperoxidase inactivates TIMP-1 by oxidizing its N-terminal cysteine residue: an oxidative mechanism for regulating proteolysis during inflammation. Wang, Y., Rosen, H., Madtes, D.K., Shao, B., Martin, T.R., Heinecke, J.W., Fu, X. J. Biol. Chem. (2007)
- Kinetic analysis of the binding of human matrix metalloproteinase-2 and -9 to tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2. Olson, M.W., Gervasi, D.C., Mobashery, S., Fridman, R. J. Biol. Chem. (1997)
- Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids of patients with temporomandibular joint osteoarthritis. Kanyama, M., Kuboki, T., Kojima, S., Fujisawa, T., Hattori, T., Takigawa, M., Yamashita, A. Journal of orofacial pain. (2000)
- Mechanisms for pro matrix metalloproteinase activation. Murphy, G., Stanton, H., Cowell, S., Butler, G., Knäuper, V., Atkinson, S., Gavrilovic, J. APMIS (1999)
- Preferential inhibition of 72- and 92-kDa gelatinases by tissue inhibitor of metalloproteinases-2. Howard, E.W., Bullen, E.C., Banda, M.J. J. Biol. Chem. (1991)
- Transcription factor early growth response 1 activity up-regulates expression of tissue inhibitor of metalloproteinases 1 in human synovial fibroblasts. Aicher, W.K., Alexander, D., Haas, C., Kuchen, S., Pagenstecher, A., Gay, S., Peter, H.H., Eibel, H. Arthritis Rheum. (2003)
- Apoptosis of human hepatic myofibroblasts promotes activation of matrix metalloproteinase-2. Preaux, A.M., D'ortho, M.P., Bralet, M.P., Laperche, Y., Mavier, P. Hepatology (2002)
- MT1-MMP, but not secreted MMPs, influences the migration of human microvascular endothelial cells in 3-dimensional collagen gels. Koike, T., Vernon, R.B., Hamner, M.A., Sadoun, E., Reed, M.J. J. Cell. Biochem. (2002)
- The role of matrilysin (MMP-7) in leukaemia cell invasion. Lynch, C.C., McDonnell, S. Clin. Exp. Metastasis (2000)
- Effects of rhDecorin on TGF-beta1 induced human hepatic stellate cells LX-2 activation. Shi, Y.F., Zhang, Q., Cheung, P.Y., Shi, L., Fong, C.C., Zhang, Y., Tzang, C.H., Chan, B.P., Fong, W.F., Chun, J., Kung, H.F., Yang, M. Biochim. Biophys. Acta (2006)
- IL-10 inhibits metalloproteinase and stimulates TIMP-1 production in human mononuclear phagocytes. Lacraz, S., Nicod, L.P., Chicheportiche, R., Welgus, H.G., Dayer, J.M. J. Clin. Invest. (1995)
- Increased matrix metalloproteinase activity and selective upregulation in LV myocardium from patients with end-stage dilated cardiomyopathy. Thomas, C.V., Coker, M.L., Zellner, J.L., Handy, J.R., Crumbley, A.J., Spinale, F.G. Circulation (1998)
- Expression and prognostic significance of metalloproteinases and their tissue inhibitors in patients with small-cell lung cancer. Michael, M., Babic, B., Khokha, R., Tsao, M., Ho, J., Pintilie, M., Leco, K., Chamberlain, D., Shepherd, F.A. J. Clin. Oncol. (1999)
- Remodeling of collagen matrix by human tumor cells requires activation and cell surface association of matrix metalloproteinase-2. Deryugina, E.I., Bourdon, M.A., Reisfeld, R.A., Strongin, A. Cancer Res. (1998)
- Expression and regulation of tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases by intestinal myofibroblasts in inflammatory bowel disease. McKaig, B.C., McWilliams, D., Watson, S.A., Mahida, Y.R. Am. J. Pathol. (2003)
- Activation of gelatinase-tissue-inhibitors-of-metalloproteinase complexes by matrilysin. von Bredow, D.C., Cress, A.E., Howard, E.W., Bowden, G.T., Nagle, R.B. Biochem. J. (1998)
- Simultaneous measurement of MMP9 and TIMP1 mRNA in human non small cell lung cancers by multiplex real time RT-PCR. Simi, L., Andreani, M., Davini, F., Janni, A., Pazzagli, M., Serio, M., Orlando, C. Lung Cancer (2004)
- Localization by in situ hybridization of mRNAs encoding stromelysin 3 and tissue inhibitors of metallo-proteinases TIMP-1 and TIMP-2 in human head and neck carcinomas. Polette, M., Clavel, C., Birembaut, P., De Clerck, Y.A. Pathol. Res. Pract. (1993)