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Gene Review: 

MAGEB1  -  melanoma antigen family B, 1

Homo sapiens

Synonyms: CT3.1, Cancer/testis antigen 3.1, DAM10, DSS-AHC critical interval MAGE superfamily 10, MAGE-B1 antigen, ...
 
 
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High impact information on MAGEB1

  • MAGE-Xp is expressed only in testis and, unlike the Xq27-qter MAGE genes, it is not expressed in any of 12 different tumor tissues tested [1].
  • We have mapped and sequenced cDNA and genomic clones corresponding to this gene, MAGE-Xp, and shown that the last exon contains the open reading frame and is present in a minimum of five copies in a 30-kb interval [1].
  • MAGE-Xp is located in the 160-kb critical interval defined for the locus involved in sex determination within Xp21 and is 50 kb distal to the DAX-1 gene, which is responsible for X-chromosome-linked adrenal hypoplasia congenita [1].
  • DAM10 and DAM6, expressed in adult testis and lung tumors [2].

References

  1. Isolation and characterization of a MAGE gene family in the Xp21.3 region. Muscatelli, F., Walker, A.P., De Plaen, E., Stafford, A.N., Monaco, A.P. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  2. A family of rapidly evolving genes from the sex reversal critical region in Xp21. Dabovic, B., Zanaria, E., Bardoni, B., Lisa, A., Bordignon, C., Russo, V., Matessi, C., Traversari, C., Camerino, G. Mamm. Genome (1995) [Pubmed]
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