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Gene Review

MAGEB2  -  melanoma antigen family B, 2

Homo sapiens

Synonyms: CT3.2, Cancer/testis antigen 3.2, DAM6, DSS-AHC critical interval MAGE superfamily 6, MAGE XP-2 antigen, ...
 
 
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Disease relevance of MAGEB2

  • We mapped the state of methylation of three of these genes, MELANOMA ANTIGEN B2 GENE (MAGEB2), METALLOPROTEINASE 2 (MMP2) and WIF1, which are involved in tumor growth and metastasis [1].
  • The D10/6-271-specific CTL clone required approximately 3 nM exogenous peptide for half-maximal lysis of target cells and was able to specifically recognize endogenous DAM antigen on HLA-A2+ melanoma cells infected with a vaccinia vector recombinant for gene DAM-6 [2].
 

High impact information on MAGEB2

References

  1. Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes. Milutinovic, S., D'Alessio, A.C., Detich, N., Szyf, M. Carcinogenesis (2007) [Pubmed]
  2. The DAM gene family encodes a new group of tumor-specific antigens recognized by human leukocyte antigen A2-restricted cytotoxic T lymphocytes. Fleischhauer, K., Gattinoni, L., Dalerba, P., Lauvau, G., Zanaria, E., Dabovic, B., van Endert, P.M., Bordignon, C., Traversari, C. Cancer Res. (1998) [Pubmed]
  3. A family of rapidly evolving genes from the sex reversal critical region in Xp21. Dabovic, B., Zanaria, E., Bardoni, B., Lisa, A., Bordignon, C., Russo, V., Matessi, C., Traversari, C., Camerino, G. Mamm. Genome (1995) [Pubmed]
  4. MAGED4-expression in renal cell carcinoma and identification of an HLA-A*25-restricted MHC class I ligand from solid tumor tissue. Krämer, B.F., Schoor, O., Krüger, T., Reichle, C., Müller, M., Weinschenk, T., Hennenlotter, J., Stenzl, A., Rammensee, H.G., Stevanovic, S. Cancer Biol. Ther. (2005) [Pubmed]
 
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