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Gene Review:

ninaG - CG6728 gene product from transcript CG6728-RB

Drosophila melanogaster

Synonyms: CG6728, Dmel\CG6728, Neither inactivation nor afterpotential protein G, NinaG

Sarfare, S. et al., Ahmad, S.T. et al.

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High impact information on ninaG

The role of Drosophila ninaG oxidoreductase in visual pigment chromophore biogenesis [1].
We further show that ninaG mutants fed on retinal as the sole source of vitamin A are able to synthesize 3-hydroxyretinoids [1].
Further, in transgenic flies expressing Rh4 as the major rhodopsin, 3-hydroxyretinal is the major retinoid in ninaG+, but a different retinoid profile is observed in ninaG(P330) [2].
The results show that when Rh1 is expressed as the major rhodopsin, ninaG flies fail to accumulate 3-hydroxyretinal [2].
A sequence analysis of the 15 open reading frames within this region from the ninaG(P330) mutant allele identified a stop codon in the CG6728 gene [2].

Associations of ninaG with chemical compounds

These results indicate that the ninaG oxidoreductase acts in the biochemical pathway responsible for conversion of retinal to the rhodopsin chromophore, 3-hydroxyretinal [2].

References

The role of Drosophila ninaG oxidoreductase in visual pigment chromophore biogenesis. Ahmad, S.T., Joyce, M.V., Boggess, B., O'Tousa, J.E. J. Biol. Chem. (2006) [Pubmed]
The Drosophila ninaG oxidoreductase acts in visual pigment chromophore production. Sarfare, S., Ahmad, S.T., Joyce, M.V., Boggess, B., O'Tousa, J.E. J. Biol. Chem. (2005) [Pubmed]

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