The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Tigason     ethyl(2E,4E,6E,8E)-9-(4- methoxy-2,3,6...

Synonyms: Retinoid, Tegison, Tigazon, Etretinato, etretinate, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Tigason


Psychiatry related information on Tigason


High impact information on Tigason


Chemical compound and disease context of Tigason


Biological context of Tigason

  • Our results suggest that interference with retinoid signalling, and not disruption of PML organization, is essential to the APL phenotype and implicates for the first time an element of the mitotic apparatus in the molecular pathogenesis of human malignancy [17].
  • To study the human teratogenicity of this agent, we investigated 154 human pregnancies with fetal exposure to isotretinoin, a retinoid prescribed for severe recalcitrant cystic acne [18].
  • Novel retinoid-related molecules as apoptosis inducers and effective inhibitors of human lung cancer cells in vivo [19].
  • Retinoid activities are mediated by specific nuclear receptors, the RARs and RXRs, which can induce transcriptional activation through specific DNA sites or by inhibiting the transcription factor AP-1 (refs 12-15), which usually mediates cell proliferation signals [20].
  • These results show that the floor plate is a local source of a ZPA-like polarizing signal, possibly a retinoid, which may regulate the pattern of cell differentiation in the developing CNS [21].

Anatomical context of Tigason

  • A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord [22].
  • Motor neuron-derived retinoid signaling specifies the subtype identity of spinal motor neurons [23].
  • Extraspinal tendon and ligament calcification associated with long-term therapy with etretinate [1].
  • These retinoids do not induce differentiation in F9 cells but inhibit effectively the proliferation of several tumour cell lines, and could thus serve as candidates for new retinoid therapeutic agents with reduced side effects [20].
  • This indicates a migration of retinoid between the two tissues, the direction of which is dictated by the state of light or dark adaptation of the photoreceptors [24].

Associations of Tigason with other chemical compounds

  • These observations suggest that retinoid X receptors meet the criteria for biochemically characterized cellular coregulators and serve to selectively target the high affinity binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate DNA response elements [25].
  • These defects were previously observed in vitamin A-deficient animals and could be prevented by RA administration, demonstrating that RAR gamma mediates some of the retinoid signal in vivo [26].
  • In the adult mouse, single and compound null mutations in the genes for retinoic acid receptor beta and retinoid X receptors beta and gamma resulted in locomotor defects related to dysfunction of the mesolimbic dopamine signaling pathway [12].
  • Interphotoreceptor retinoid-binding protein (IRBP), a glycoprotein specific for the retina and pineal gland, induces inflammatory changes in these two organs in immunized animals [27].
  • Although overexpression of a constitutively active Akt in premalignant and malignant HBE cells had no effect on growth inhibition mediated by N-(4-hydroxyphenyl)retinamide (4-HPR), a novel chemopreventive retinoid, it blocked deguelin-induced growth arrest and apoptosis [28].

Gene context of Tigason


Analytical, diagnostic and therapeutic context of Tigason


  1. Extraspinal tendon and ligament calcification associated with long-term therapy with etretinate. DiGiovanna, J.J., Helfgott, R.K., Gerber, L.H., Peck, G.L. N. Engl. J. Med. (1986) [Pubmed]
  2. Central hypothyroidism associated with retinoid X receptor-selective ligands. Sherman, S.I., Gopal, J., Haugen, B.R., Chiu, A.C., Whaley, K., Nowlakha, P., Duvic, M. N. Engl. J. Med. (1999) [Pubmed]
  3. Plasminogen activator in chick fibroblasts: induction of synthesis by retinoic acid; synergism with viral transformation and phorbol ester. Wilson, E.L., Reich, E. Cell (1978) [Pubmed]
  4. Evidence for defective retinoid transport and function in late onset Alzheimer's disease. Goodman, A.B., Pardee, A.B. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  5. Reduced retinoid content in hepatocellular carcinoma with special reference to alcohol consumption. Adachi, S., Moriwaki, H., Muto, Y., Yamada, Y., Fukutomi, Y., Shimazaki, M., Okuno, M., Ninomiya, M. Hepatology (1991) [Pubmed]
  6. Developmentally-related candidate retinoic acid target genes regulated early during neuronal differentiation of human embryonal carcinoma. Freemantle, S.J., Kerley, J.S., Olsen, S.L., Gross, R.H., Spinella, M.J. Oncogene (2002) [Pubmed]
  7. Diet and breast cancer: can dietary factors influence survival? Rock, C.L. Journal of mammary gland biology and neoplasia. (2003) [Pubmed]
  8. Nuclear hormone receptors and gene expression. Aranda, A., Pascual, A. Physiol. Rev. (2001) [Pubmed]
  9. Retinoids in embryonal development. Ross, S.A., McCaffery, P.J., Drager, U.C., De Luca, L.M. Physiol. Rev. (2000) [Pubmed]
  10. Rpe65 is the retinoid isomerase in bovine retinal pigment epithelium. Jin, M., Li, S., Moghrabi, W.N., Sun, H., Travis, G.H. Cell (2005) [Pubmed]
  11. A photic visual cycle of rhodopsin regeneration is dependent on Rgr. Chen, P., Hao, W., Rife, L., Wang, X.P., Shen, D., Chen, J., Ogden, T., Van Boemel, G.B., Wu, L., Yang, M., Fong, H.K. Nat. Genet. (2001) [Pubmed]
  12. Impaired locomotion and dopamine signaling in retinoid receptor mutant mice. Krezel, W., Ghyselinck, N., Samad, T.A., Dupé, V., Kastner, P., Borrelli, E., Chambon, P. Science (1998) [Pubmed]
  13. Antiproliferative effect of retinoid compounds on Kaposi's sarcoma cells. Corbeil, J., Rapaport, E., Richman, D.D., Looney, D.J. J. Clin. Invest. (1994) [Pubmed]
  14. Growth inhibition and induction of apoptosis by fenretinide in small-cell lung cancer cell lines. Kalemkerian, G.P., Slusher, R., Ramalingam, S., Gadgeel, S., Mabry, M. J. Natl. Cancer Inst. (1995) [Pubmed]
  15. Modulation of the metastatic phenotype by 13-cis-retinoic acid. Couch, M.J., Pauli, B.U., Weinstein, R.S., Coon, J.S. J. Natl. Cancer Inst. (1987) [Pubmed]
  16. Antitumor activity of vitamin A and its derivatives. Muto, Y., Moriwaki, H. J. Natl. Cancer Inst. (1984) [Pubmed]
  17. Fusion of retinoic acid receptor alpha to NuMA, the nuclear mitotic apparatus protein, by a variant translocation in acute promyelocytic leukaemia. Wells, R.A., Catzavelos, C., Kamel-Reid, S. Nat. Genet. (1997) [Pubmed]
  18. Retinoic acid embryopathy. Lammer, E.J., Chen, D.T., Hoar, R.M., Agnish, N.D., Benke, P.J., Braun, J.T., Curry, C.J., Fernhoff, P.M., Grix, A.W., Lott, I.T. N. Engl. J. Med. (1985) [Pubmed]
  19. Novel retinoid-related molecules as apoptosis inducers and effective inhibitors of human lung cancer cells in vivo. Lu, X.P., Fanjul, A., Picard, N., Pfahl, M., Rungta, D., Nared-Hood, K., Carter, B., Piedrafita, J., Tang, S., Fabbrizio, E., Pfahl, M. Nat. Med. (1997) [Pubmed]
  20. A new class of retinoids with selective inhibition of AP-1 inhibits proliferation. Fanjul, A., Dawson, M.I., Hobbs, P.D., Jong, L., Cameron, J.F., Harlev, E., Graupner, G., Lu, X.P., Pfahl, M. Nature (1994) [Pubmed]
  21. Polarizing activity and retinoid synthesis in the floor plate of the neural tube. Wagner, M., Thaller, C., Jessell, T., Eichele, G. Nature (1990) [Pubmed]
  22. A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord. Pierani, A., Brenner-Morton, S., Chiang, C., Jessell, T.M. Cell (1999) [Pubmed]
  23. Motor neuron-derived retinoid signaling specifies the subtype identity of spinal motor neurons. Sockanathan, S., Jessell, T.M. Cell (1998) [Pubmed]
  24. Interphotoreceptor retinol-binding proteins: possible transport vehicles between compartments of the retina. Lai, Y.L., Wiggert, B., Liu, Y.P., Chader, G.J. Nature (1982) [Pubmed]
  25. RXR beta: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements. Yu, V.C., Delsert, C., Andersen, B., Holloway, J.M., Devary, O.V., Näär, A.M., Kim, S.Y., Boutin, J.M., Glass, C.K., Rosenfeld, M.G. Cell (1991) [Pubmed]
  26. Function of retinoic acid receptor gamma in the mouse. Lohnes, D., Kastner, P., Dierich, A., Mark, M., LeMeur, M., Chambon, P. Cell (1993) [Pubmed]
  27. Identification of an immunodominant and highly immunopathogenic determinant in the retinal interphotoreceptor retinoid-binding protein (IRBP). Sanui, H., Redmond, T.M., Kotake, S., Wiggert, B., Hu, L.H., Margalit, H., Berzofsky, J.A., Chader, G.J., Gery, I. J. Exp. Med. (1989) [Pubmed]
  28. Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells. Chun, K.H., Kosmeder, J.W., Sun, S., Pezzuto, J.M., Lotan, R., Hong, W.K., Lee, H.Y. J. Natl. Cancer Inst. (2003) [Pubmed]
  29. Functional ecdysone receptor is the product of EcR and Ultraspiracle genes. Yao, T.P., Forman, B.M., Jiang, Z., Cherbas, L., Chen, J.D., McKeown, M., Cherbas, P., Evans, R.M. Nature (1993) [Pubmed]
  30. Role of the histone deacetylase complex in acute promyelocytic leukaemia. Lin, R.J., Nagy, L., Inoue, S., Shao, W., Miller, W.H., Evans, R.M. Nature (1998) [Pubmed]
  31. Heterodimerization of the Drosophila ecdysone receptor with retinoid X receptor and ultraspiracle. Thomas, H.E., Stunnenberg, H.G., Stewart, A.F. Nature (1993) [Pubmed]
  32. BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect. Hallahan, A.R., Pritchard, J.I., Chandraratna, R.A., Ellenbogen, R.G., Geyer, J.R., Overland, R.P., Strand, A.D., Tapscott, S.J., Olson, J.M. Nat. Med. (2003) [Pubmed]
  33. All-trans retinoic acid converts E2F into a transcriptional suppressor and inhibits the growth of normal human bronchial epithelial cells through a retinoic acid receptor- dependent signaling pathway. Lee, H.Y., Dohi, D.F., Kim, Y.H., Walsh, G.L., Consoli, U., Andreeff, M., Dawson, M.I., Hong, W.K., Kurie, J.M. J. Clin. Invest. (1998) [Pubmed]
  34. Retinoid chemoprevention trial begins against bladder cancer. Gunby, P. JAMA (1978) [Pubmed]
  35. Retinoic acid receptor beta expression and growth inhibition of gynecologic cancer cells by the synthetic retinoid N-(4-hydroxyphenyl) retinamide. Sabichi, A.L., Hendricks, D.T., Bober, M.A., Birrer, M.J. J. Natl. Cancer Inst. (1998) [Pubmed]
  36. A ligand of peroxisome proliferator-activated receptor gamma, retinoids, and prevention of preneoplastic mammary lesions. Mehta, R.G., Williamson, E., Patel, M.K., Koeffler, H.P. J. Natl. Cancer Inst. (2000) [Pubmed]
  37. Expression of retinoid receptor genes and proteins in non-small-cell lung cancer. Picard, E., Seguin, C., Monhoven, N., Rochette-Egly, C., Siat, J., Borrelly, J., Martinet, Y., Martinet, N., Vignaud, J.M. J. Natl. Cancer Inst. (1999) [Pubmed]
  38. Molecular epidemiology and retinoid chemoprevention of head and neck cancer. Khuri, F.R., Lippman, S.M., Spitz, M.R., Lotan, R., Hong, W.K. J. Natl. Cancer Inst. (1997) [Pubmed]
WikiGenes - Universities