Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Fer3 - 48 related 3

Drosophila melanogaster

Synonyms: Basic helix-loop-helix protein N-twist, BcDNA:LD04689, CG6913, Dmel\CG6913, Dnato3, ...

Verzi, M.P. et al.

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High impact information on Fer3

This neural expression is conserved in invertebrates, as expression of the Drosophila ortholog of N-twist is also restricted to the central nervous system [1].
We show that N-Twist inhibits MASH1-dependent transcriptional activation by sequestering E protein in a dominant negative fashion [1].
Here we report the identification and initial characterization of the bHLH gene, Neuronal twist (N-twist), named for its neural expression pattern and high sequence homology and physical linkage to the mesodermal inhibitor, M-twist [1].

References

N-twist, an evolutionarily conserved bHLH protein expressed in the developing CNS, functions as a transcriptional inhibitor. Verzi, M.P., Anderson, J.P., Dodou, E., Kelly, K.K., Greene, S.B., North, B.J., Cripps, R.M., Black, B.L. Dev. Biol. (2002) [Pubmed]

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