Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

MBD-R2 - CG10042 gene product from transcript...

Drosophila melanogaster

Synonyms: CG10042, CG17393, Dm Tam3, Dmel\CG10042, MBD, ...

Calvi, B.R. et al., Rommens, C.M. et al., Atkinson, P.W. et al.

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High impact information on MBD-R2

The 2959 bp HFL1 sequence predicts a 2.0 kb open reading frame (ORF1) with substantial amino acid similarity to the transposases of Activator (Ac) from maize (Zea mays) and Tam3 from snapdragon (Antirrhinum majus) [1].
We discuss the possibility that the conservation of hobo, Ac, and Tam3 transposases represents an example of horizontal transmission of genetic information between plants and animals [1].
DNA sequences displaying high homology to the hobo transposase gene were isolated from the genome of M. domestica and appear to be part of a mobile-element system related to hobo, Ac, and Tam3 [2].

Analytical, diagnostic and therapeutic context of MBD-R2

Excision products generated by the plant transposable elements Ac and Tam3 imply a more or less straightforward ligation of broken ends; excision products of the Drosophila P element indicate the involvement of 'double-strand break' (DSB) repair [3].

References

Evidence for a common evolutionary origin of inverted repeat transposons in Drosophila and plants: hobo, Activator, and Tam3. Calvi, B.R., Hong, T.J., Findley, S.D., Gelbart, W.M. Cell (1991) [Pubmed]
The hobo transposable element of Drosophila can be cross-mobilized in houseflies and excises like the Ac element of maize. Atkinson, P.W., Warren, W.D., O'Brochta, D.A. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
Differential repair of excision gaps generated by transposable elements of the 'Ac family'. Rommens, C.M., van Haaren, M.J., Nijkamp, H.J., Hille, J. Bioessays (1993) [Pubmed]

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