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Gene Review:

wntD - wnt inhibitor of Dorsal

Drosophila melanogaster

Synonyms: CG8458, DWnt-8, DWnt8, Dm DWnt8, Dmel\CG8458, ...

Gordon, M.D. et al., Ganguly, A. et al., Wang, S. et al.

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High impact information on wntD

The expression of wntD is activated by Dorsal and Twist, but the expression is much reduced in the ventral cells through repression by Snail [1].
Frzb-1, an antagonist of Wnt-1 and Wnt-8, does not block signaling by Wnts -3A, -5A, or -11 [2].
By engineering a gene knockout, we show that wntD loss-of-function mutants have immune defects and exhibit increased levels of Toll/Dorsal signalling [3].
Furthermore, the wntD mutant phenotype is suppressed by loss of zygotic dorsal [3].

References

Drosophila WntD is a target and an inhibitor of the Dorsal/Twist/Snail network in the gastrulating embryo. Ganguly, A., Jiang, J., Ip, Y.T. Development (2005) [Pubmed]
Frzb-1, an antagonist of Wnt-1 and Wnt-8, does not block signaling by Wnts -3A, -5A, or -11. Wang, S., Krinks, M., Moos, M. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
WntD is a feedback inhibitor of Dorsal/NF-kappaB in Drosophila development and immunity. Gordon, M.D., Dionne, M.S., Schneider, D.S., Nusse, R. Nature (2005) [Pubmed]

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