Gene Review:
wg - wingless
Drosophila melanogaster
Synonyms:
Br, CG4889, DWint-1, DWnt-1, Dint-1, ...
- Mutual antagonism between signals secreted by adjacent wingless and engrailed cells leads to specification of complementary regions of the Drosophila parasegment. Gritzan, U., Hatini, V., DiNardo, S. Development (1999)
- BCL9-2 binds Arm/beta-catenin in a Tyr142-independent manner and requires Pygopus for its function in Wg/Wnt signaling. Hoffmans, R., Basler, K. Mech. Dev. (2007)
- Expression of Wnt-1 in PC12 cells results in modulation of plakoglobin and E-cadherin and increased cellular adhesion. Bradley, R.S., Cowin, P., Brown, A.M. J. Cell Biol. (1993)
- A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23. Wang, Y.K., Samos, C.H., Peoples, R., Pérez-Jurado, L.A., Nusse, R., Francke, U. Hum. Mol. Genet. (1997)
- Drosophila wingless: a paradigm for the function and mechanism of Wnt signaling. Siegfried, E., Perrimon, N. Bioessays (1994)
- Intercellular signalling in Drosophila segment formation reconstructed in vitro. Cumberledge, S., Krasnow, M.A. Nature (1993)
- Wntless, a conserved membrane protein dedicated to the secretion of wnt proteins from signaling cells. Bänziger, C., Soldini, D., Schütt, C., Zipperlen, P., Hausmann, G., Basler, K. Cell (2006)
- Boca, an endoplasmic reticulum protein required for wingless signaling and trafficking of LDL receptor family members in Drosophila. Culi, J., Mann, R.S. Cell (2003)
- Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution. Sollars, V., Lu, X., Xiao, L., Wang, X., Garfinkel, M.D., Ruden, D.M. Nat. Genet. (2003)
- Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1. Price, M.A., Kalderon, D. Cell (2002)
- wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate. Siegfried, E., Chou, T.B., Perrimon, N. Cell (1992)
- Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning. Lepage, T., Cohen, S.M., Diaz-Benjumea, F.J., Parkhurst, S.M. Nature (1995)
- Components of wingless signalling in Drosophila. Siegfried, E., Wilder, E.L., Perrimon, N. Nature (1994)
- Requirement for Pangolin/dTCF in Drosophila Wingless signaling. Schweizer, L., Nellen, D., Basler, K. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Regulation of segment polarity genes in the Drosophila blastoderm by fushi tarazu and even skipped. Ingham, P.W., Baker, N.E., Martinez-Arias, A. Nature (1988)
- Homeotic genes regulate the spatial expression of putative growth factors in the visceral mesoderm of Drosophila embryos. Reuter, R., Panganiban, G.E., Hoffmann, F.M., Scott, M.P. Development (1990)
- Expression of wingless in the Drosophila embryo: a conserved cis-acting element lacking conserved Ci-binding sites is required for patched-mediated repression. Lessing, D., Nusse, R. Development (1998)
- A novel homeobox gene mediates the Dpp signal to establish functional specificity within target cells. Nakagoshi, H., Hoshi, M., Nabeshima, Y., Matsuzaki, F. Genes Dev. (1998)
- Combgap relays wingless signal reception to the determination of cortical cell fate in the Drosophila visual system. Song, Y., Chung, S., Kunes, S. Mol. Cell (2000)
- Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C. Cook, D., Fry, M.J., Hughes, K., Sumathipala, R., Woodgett, J.R., Dale, T.C. EMBO J. (1996)
- Defects in glucuronate biosynthesis disrupt Wingless signaling in Drosophila. Haerry, T.E., Heslip, T.R., Marsh, J.L., O'Connor, M.B. Development (1997)
- Regulation of the protein kinase activity of Shaggy(Zeste-white3) by components of the wingless pathway in Drosophila cells and embryos. Ruel, L., Stambolic, V., Ali, A., Manoukian, A.S., Woodgett, J.R. J. Biol. Chem. (1999)
- Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells. Stambolic, V., Ruel, L., Woodgett, J.R. Curr. Biol. (1996)
- Drosophila segment polarity gene product porcupine stimulates the posttranslational N-glycosylation of wingless in the endoplasmic reticulum. Tanaka, K., Kitagawa, Y., Kadowaki, T. J. Biol. Chem. (2002)
- A role of Dishevelled in relocating Axin to the plasma membrane during wingless signaling. Cliffe, A., Hamada, F., Bienz, M. Curr. Biol. (2003)
- The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila. Tsuda, M., Kamimura, K., Nakato, H., Archer, M., Staatz, W., Fox, B., Humphrey, M., Olson, S., Futch, T., Kaluza, V., Siegfried, E., Stam, L., Selleck, S.B. Nature (1999)
- Osa-containing Brahma chromatin remodeling complexes are required for the repression of wingless target genes. Collins, R.T., Treisman, J.E. Genes Dev. (2000)
- Ligand receptor interactions in the Wnt signaling pathway in Drosophila. Wu, C.H., Nusse, R. J. Biol. Chem. (2002)
- Functional studies of shaggy/glycogen synthase kinase 3 phosphorylation sites in Drosophila melanogaster. Papadopoulou, D., Bianchi, M.W., Bourouis, M. Mol. Cell. Biol. (2004)
- Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc. de Celis, J.F., Garcia-Bellido, A., Bray, S.J. Development (1996)
- The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate. Micchelli, C.A., Rulifson, E.J., Blair, S.S. Development (1997)
- The hiiragi gene encodes a poly(A) polymerase, which controls the formation of the wing margin in Drosophila melanogaster. Murata, T., Nagaso, H., Kashiwabara , S., Baba, T., Okano, H., Yokoyama, K.K. Dev. Biol. (2001)
- Leg development in flies versus grasshoppers: differences in dpp expression do not lead to differences in the expression of downstream components of the leg patterning pathway. Jockusch, E.L., Nulsen, C., Newfeld, S.J., Nagy, L.M. Development (2000)
- Complementary and mutually exclusive activities of decapentaplegic and wingless organize axial patterning during Drosophila leg development. Jiang, J., Struhl, G. Cell (1996)
- Distinct pathways for autocrine and paracrine Wingless signalling in Drosophila embryos. Hooper, J.E. Nature (1994)
- Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb. Jiang, J., Struhl, G. Nature (1998)
- Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling. Lin, X., Perrimon, N. Nature (1999)
- Decapentaplegic restricts the domain of wingless during Drosophila limb patterning. Penton, A., Hoffmann, F.M. Nature (1996)
- The retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi network. Belenkaya, T.Y., Wu, Y., Tang, X., Zhou, B., Cheng, L., Sharma, Y.V., Yan, D., Selva, E.M., Lin, X. Dev. Cell (2008)
- Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains. Tran, H., Hamada, F., Schwarz-Romond, T., Bienz, M. Genes Dev. (2008)
- The dishevelled protein is modified by wingless signaling in Drosophila. Yanagawa, S., van Leeuwen, F., Wodarz, A., Klingensmith, J., Nusse, R. Genes Dev. (1995)
- Proteoglycans and pattern formation: sugar biochemistry meets developmental genetics. Selleck, S.B. Trends Genet. (2000)
- Regulation of cellular plasticity in Drosophila imaginal disc cells by the Polycomb group, trithorax group and lama genes. Klebes, A., Sustar, A., Kechris, K., Li, H., Schubiger, G., Kornberg, T.B. Development (2005)
- WNT/PCP signaling pathway and human cancer (review). Katoh, M. Oncol. Rep. (2005)
- Transcription of the segment-polarity gene wingless in the imaginal discs of Drosophila, and the phenotype of a pupal-lethal wg mutation. Baker, N.E. Development (1988)