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Gene Review

frzb-1  -  Frzb-1 protein

Xenopus laevis

Synonyms: Sfrp3, frezzled, frzb
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High impact information on Frzb-1

  • These observations implicate Frzb in axial patterning and support the concept that Frzb binds and inactivates Xwnt-8 during gastrulation, preventing inappropriate ventral signaling in developing dorsal tissues [1].
  • Unlike Frizzled proteins, endogenous Frzb was soluble [1].
  • Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8 [1].
  • Gsc acts in deeper vegetal cells, where it regulates Frzb expression to maintain Xnot expression in the neighbouring notochord territory [2].
  • Reciprocally, Xnr2 induced dorsoanterior endodermal markers, such as cerberus, Xhex-1 and Frzb, in animal cap ectoderm [3].

Anatomical context of Frzb-1

  • Siamois induces Cerberus, Frzb1 and Xlim1 in vegetal blastomeres and vegetal induction by Siamois is dependent on endogenous TGFbeta signals [4].

Other interactions of Frzb-1

  • Furthermore, Frzb blocked induction of MyoD, an action reported recently for a dominant-negative Xwnt-8 [1].
  • A direct screen for secreted proteins in Xenopus embryos identifies distinct activities for the Wnt antagonists Crescent and Frzb-1 [5].
  • Consistent with the absence of head organizer activity in Siamois-expressing animal pole tissue, Siamois did not induce animal expression of Cerberus, Frzb1 and Xlim1, genes implicated in anterior development [4].


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