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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Mf  -  Myofilin

Drosophila melanogaster

Synonyms: BcDNA:GH23305, CG6803, DmMf, Dmel\CG6803, Zeelin1, ...
 
 
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High impact information on Zeelin1

  • This mutation, which in vivo is antagonistic to z1 and does not support transvection effects, can be made to revert its phenotype when the mutant protein is over-produced under the control of the heat shock promoter [1].
  • When the z1 protein is over-produced in vivo, it reduces the expression of an unpaired copy of white, indicating that the normal requirement for chromosome pairing is simply a device to increase the size of the aggregate bound to the white regulatory region [1].
  • Zeelin 2, which is on the outside of Lethocerus flight muscle thick filaments, has been sequenced and because of the similarity to Drosophila flightin, is re-named flightin [2].

References

  1. Self-association of the Drosophila zeste protein is responsible for transvection effects. Bickel, S., Pirrotta, V. EMBO J. (1990) [Pubmed]
  2. Myofilin, a protein in the thick filaments of insect muscle. Qiu, F., Brendel, S., Cunha, P.M., Astola, N., Song, B., Furlong, E.E., Leonard, K.R., Bullard, B. J. Cell. Sci. (2005) [Pubmed]
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