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Gene Review:

RhoGAP93B - Rho GTPase activating protein at 93B

Drosophila melanogaster

Synonyms: CG3421, CrGAP, Dmel\CG3421, Vilse, vilse

Lundström, A. et al.

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High impact information on RhoGAP93B

Vilse and its human homolog bind directly to the intracellular domains of the corresponding Robo receptors and promote the hydrolysis of RacGTP and, less efficiently, of Cdc42GTP [1].
Vilse defines a conserved family of RhoGAPs (Rho GTPase-activating proteins), with representatives in flies and vertebrates [1].

Anatomical context of RhoGAP93B

We describe the functional analysis of vilse, a Drosophila gene required for Robo repulsion in epithelial cells and axons [1].

References

Vilse, a conserved Rac/Cdc42 GAP mediating Robo repulsion in tracheal cells and axons. Lundström, A., Gallio, M., Englund, C., Steneberg, P., Hemphälä, J., Aspenström, P., Keleman, K., Falileeva, L., Dickson, B.J., Samakovlis, C. Genes Dev. (2004) [Pubmed]

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