Gene Review:
robo - roundabout
Drosophila melanogaster
Synonyms:
BEST:GM07780, CG13521, CT32892, D-Robo1, Dmel\CG13521, ...
- Comm sorts robo to control axon guidance at the Drosophila midline. Keleman, K., Rajagopalan, S., Cleppien, D., Teis, D., Paiha, K., Huber, L.A., Technau, G.M., Dickson, B.J. Cell (2002)
- Slit is the midline repellent for the robo receptor in Drosophila. Kidd, T., Bland, K.S., Goodman, C.S. Cell (1999)
- Regulation of commissural axon pathfinding by slit and its robo receptors. Dickson, B.J., Gilestro, G.F. Annu. Rev. Cell Dev. Biol. (2006)
- Switching repulsion to attraction: changing responses to slit during transition in mesoderm migration. Kramer, S.G., Kidd, T., Simpson, J.H., Goodman, C.S. Science (2001)
- ROBO directs axon crossing of segmental boundaries by suppressing responsiveness to relocalized Netrin. Hiramoto, M., Hiromi, Y. Nat. Neurosci. (2006)
- Slit coordinates cardiac morphogenesis in Drosophila. Macmullin, A., Jacobs, J.R. Dev. Biol. (2006)
- Lateral positioning at the dorsal midline: Slit and Roundabout receptors guide Drosophila heart cell migration. Santiago-Martínez, E., Soplop, N.H., Kramer, S.G. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Slit and Robo control cardiac cell polarity and morphogenesis. Qian, L., Liu, J., Bodmer, R. Curr. Biol. (2005)
- Compartmentalization of visual centers in the Drosophila brain requires Slit and Robo proteins. Tayler, T.D., Robichaux, M.B., Garrity, P.A. Development (2004)
- Mutations affecting growth cone guidance in Drosophila: genes necessary for guidance toward or away from the midline. Seeger, M., Tear, G., Ferres-Marco, D., Goodman, C.S. Neuron (1993)
- Heparan sulfate proteoglycan syndecan promotes axonal and myotube guidance by slit/robo signaling. Steigemann, P., Molitor, A., Fellert, S., Jäckle, H., Vorbrüggen, G. Curr. Biol. (2004)
- Roundabout gene family functions during sensory axon guidance in the drosophila embryo are mediated by both Slit-dependent and Slit-independent mechanisms. Parsons, L., Harris, K.L., Turner, K., Whitington, P.M. Dev. Biol. (2003)
- Effects of roundabout on growth cone dynamics, filopodial length, and growth cone morphology at the midline and throughout the neuropile. Murray, M.J., Whitington, P.M. J. Neurosci. (1999)
- Independent functions of Slit-Robo repulsion and Netrin-Frazzled attraction regulate axon crossing at the midline in Drosophila. Garbe, D.S., Bashaw, G.J. J. Neurosci. (2007)
- Binding site for Robo receptors revealed by dissection of the leucine-rich repeat region of Slit. Howitt, J.A., Clout, N.J., Hohenester, E. EMBO J. (2004)
- Structural and functional analysis of slit and heparin binding to immunoglobulin-like domains 1 and 2 of Drosophila Robo. Fukuhara, N., Howitt, J.A., Hussain, S.A., Hohenester, E. J. Biol. Chem. (2008)
- Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons. Li, H.S., Chen, J.H., Wu, W., Fagaly, T., Zhou, L., Yuan, W., Dupuis, S., Jiang, Z.H., Nash, W., Gick, C., Ornitz, D.M., Wu, J.Y., Rao, Y. Cell (1999)
- Vilse, a conserved Rac/Cdc42 GAP mediating Robo repulsion in tracheal cells and axons. Lundström, A., Gallio, M., Englund, C., Steneberg, P., Hemphälä, J., Aspenström, P., Keleman, K., Falileeva, L., Dickson, B.J., Samakovlis, C. Genes Dev. (2004)
- Receptor tyrosine phosphatases regulate axon guidance across the midline of the Drosophila embryo. Sun, Q., Bahri, S., Schmid, A., Chia, W., Zinn, K. Development (2000)
- Short-range and long-range guidance by Slit and its Robo receptors: a combinatorial code of Robo receptors controls lateral position. Simpson, J.H., Bland, K.S., Fetter, R.D., Goodman, C.S. Cell (2000)
- Regulation of rho family GTPases is required to prevent axons from crossing the midline. Fritz, J.L., VanBerkum, M.F. Dev. Biol. (2002)
- Dosage-sensitive and complementary functions of roundabout and commissureless control axon crossing of the CNS midline. Kidd, T., Russell, C., Goodman, C.S., Tear, G. Neuron (1998)
- Positioning sensory terminals in the olfactory lobe of Drosophila by Robo signaling. Jhaveri, D., Saharan, S., Sen, A., Rodrigues, V. Development (2004)
- {beta}-Spectrin functions independently of Ankyrin to regulate the establishment and maintenance of axon connections in the Drosophila embryonic CNS. Garbe, D.S., Das, A., Dubreuil, R.R., Bashaw, G.J. Development (2007)
- A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding. Wills, Z., Emerson, M., Rusch, J., Bikoff, J., Baum, B., Perrimon, N., Van Vactor, D. Neuron (2002)
- The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance. Yuan, W., Zhou, L., Chen, J.H., Wu, J.Y., Rao, Y., Ornitz, D.M. Dev. Biol. (1999)