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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

E(spl)mdelta-HLH  -  Enhancer of split mdelta, helix-loop-helix

Drosophila melanogaster

Synonyms: CG8328, Dmel\CG8328, E(Spl) HLH-m delta, E(Spl)-HLH-mdelta, E(spl) mdelta, ...
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High impact information on HLHmdelta


Biological context of HLHmdelta

  • In addition, using the conditional phenotype of the Su(dx)(sp) allele, we show that loss of Su(dx) activity is rapidly followed by an up-regulation of E(spl)mbeta expression, the immediate target of Notch signal activation during wing vein development [2].

Other interactions of HLHmdelta

  • These observations were extended to the molecular level by demonstrating that the expression of Enhancer of split mdelta, a target of Notch signaling, is down-regulated by SERS [3].


  1. Frizzled regulation of Notch signalling polarizes cell fate in the Drosophila eye. Cooper, M.T., Bray, S.J. Nature (1999) [Pubmed]
  2. Down-regulation of Notch target gene expression by Suppressor of deltex. Mazaleyrat, S.L., Fostier, M., Wilkin, M.B., Aslam, H., Evans, D.A., Cornell, M., Baron, M. Dev. Biol. (2003) [Pubmed]
  3. Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila. Sun, X., Artavanis-Tsakonas, S. Development (1997) [Pubmed]
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