Gene Review:
N - Notch
Drosophila melanogaster
Synonyms:
1.1, 16-178, 16-55, Ax, CG3936, ...
- Fringe modulates Notch-ligand interactions. Panin, V.M., Papayannopoulos, V., Wilson, R., Irvine, K.D. Nature (1997)
- Echinoid mutants exhibit neurogenic phenotypes and show synergistic interactions with the Notch signaling pathway. Ahmed, A., Chandra, S., Magarinos, M., Vaessin, H. Development (2003)
- Serrate-Notch signaling defines the scope of the initial denticle field by modulating EGFR activation. Walters, J.W., Muñoz, C., Paaby, A.B., Dinardo, S. Dev. Biol. (2005)
- Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei. Lieber, T., Kidd, S., Alcamo, E., Corbin, V., Young, M.W. Genes Dev. (1993)
- Wasp, the Drosophila Wiskott-Aldrich syndrome gene homologue, is required for cell fate decisions mediated by Notch signaling. Ben-Yaacov, S., Le Borgne , R., Abramson, I., Schweisguth, F., Schejter, E.D. J. Cell Biol. (2001)
- Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila. Chung, H.M., Struhl, G. Nat. Cell Biol. (2001)
- Notch is required for long-term memory in Drosophila. Presente, A., Boyles, R.S., Serway, C.N., de Belle, J.S., Andres, A.J. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Proneural gene self-stimulation in neural precursors: an essential mechanism for sense organ development that is regulated by Notch signaling. Culí, J., Modolell, J. Genes Dev. (1998)
- The Drosophila Notch Inhibitor and Tumor Suppressor Gene lethal (2) giant discs Encodes a Conserved Regulator of Endosomal Trafficking. Jaekel, R., Klein, T. Dev. Cell (2006)
- EGFR signaling attenuates Groucho-dependent repression to antagonize Notch transcriptional output. Hasson, P., Egoz, N., Winkler, C., Volohonsky, G., Jia, S., Dinur, T., Volk, T., Courey, A.J., Paroush, Z. Nat. Genet. (2005)
- Asymmetric Rab 11 endosomes regulate delta recycling and specify cell fate in the Drosophila nervous system. Emery, G., Hutterer, A., Berdnik, D., Mayer, B., Wirtz-Peitz, F., Gaitan, M.G., Knoblich, J.A. Cell (2005)
- t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. Tonon, G., Modi, S., Wu, L., Kubo, A., Coxon, A.B., Komiya, T., O'Neil, K., Stover, K., El-Naggar, A., Griffin, J.D., Kirsch, I.R., Kaye, F.J. Nat. Genet. (2003)
- Regulation of notch signaling by o-linked fucose. Okajima, T., Irvine, K.D. Cell (2002)
- The homeobox gene mirror links EGF signalling to embryonic dorso-ventral axis formation through notch activation. Jordan, K.C., Clegg, N.J., Blasi, J.A., Morimoto, A.M., Sen, J., Stein, D., McNeill, H., Deng, W.M., Tworoger, M., Ruohola-Baker, H. Nat. Genet. (2000)
- Novel signaling from the peripodial membrane is essential for eye disc patterning in Drosophila. Cho, K.O., Chern, J., Izaddoost, S., Choi, K.W. Cell (2000)
- Wingless and Notch regulate cell-cycle arrest in the developing Drosophila wing. Johnston, L.A., Edgar, B.A. Nature (1998)
- Delta and Serrate are redundant Notch ligands required for asymmetric cell divisions within the Drosophila sensory organ lineage. Zeng, C., Younger-Shepherd, S., Jan, L.Y., Jan, Y.N. Genes Dev. (1998)
- Control of daughter cell fates during asymmetric division: interaction of Numb and Notch. Guo, M., Jan, L.Y., Jan, Y.N. Neuron (1996)
- The enhancer of split complex of Drosophila includes four Notch-regulated members of the bearded gene family. Lai, E.C., Bodner, R., Posakony, J.W. Development (2000)
- Notch signalling and the initiation of neural development in the Drosophila eye. Baonza, A., Freeman, M. Development (2001)
- The daughterless gene functions together with Notch and Delta in the control of ovarian follicle development in Drosophila. Cummings, C.A., Cronmiller, C. Development (1994)
- Regulation of notch endosomal sorting and signaling by Drosophila Nedd4 family proteins. Wilkin, M.B., Carbery, A.M., Fostier, M., Aslam, H., Mazaleyrat, S.L., Higgs, J., Myat, A., Evans, D.A., Cornell, M., Baron, M. Curr. Biol. (2004)
- Reciprocal regulatory interactions between the Notch and Ras signaling pathways in the Drosophila embryonic mesoderm. Carmena, A., Buff, E., Halfon, M.S., Gisselbrecht, S., Jiménez, F., Baylies, M.K., Michelson, A.M. Dev. Biol. (2002)
- Expression and function of decapentaplegic and thick veins during the differentiation of the veins in the Drosophila wing. de Celis, J.F. Development (1997)
- Notch pathway repression by vestigial is required to promote indirect flight muscle differentiation in Drosophila melanogaster. Bernard, F., Dutriaux, A., Silber, J., Lalouette, A. Dev. Biol. (2006)
- Drosophila Gp150 is required for early ommatidial development through modulation of Notch signaling. Fetchko, M., Huang, W., Li, Y., Lai, Z.C. EMBO J. (2002)
- Notch-induced proteolysis and nuclear localization of the Delta ligand. Bland, C.E., Kimberly, P., Rand, M.D. J. Biol. Chem. (2003)
- Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation. Sakata, T., Sakaguchi, H., Tsuda, L., Higashitani, A., Aigaki, T., Matsuno, K., Hayashi, S. Curr. Biol. (2004)
- Ligand-binding and signaling properties of the Ax[M1] form of Notch. Pérez, L., Milán, M., Bray, S., Cohen, S.M. Mech. Dev. (2005)
- An O-fucose site in the ligand binding domain inhibits Notch activation. Lei, L., Xu, A., Panin, V.M., Irvine, K.D. Development (2003)
- Two different activities of Suppressor of Hairless during wing development in Drosophila. Klein, T., Seugnet, L., Haenlin, M., Martinez Arias, A. Development (2000)
- Cell division genes promote asymmetric interaction between Numb and Notch in the Drosophila CNS. Wai, P., Truong, B., Bhat, K.M. Development (1999)
- Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc. de Celis, J.F., Garcia-Bellido, A., Bray, S.J. Development (1996)
- Frizzled regulation of Notch signalling polarizes cell fate in the Drosophila eye. Cooper, M.T., Bray, S.J. Nature (1999)
- Inducible RNA interference uncovers the Drosophila protein Bx42 as an essential nuclear cofactor involved in Notch signal transduction. Negeri, D., Eggert, H., Gienapp, R., Saumweber, H. Mech. Dev. (2002)
- Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins. Stifani, S., Blaumueller, C.M., Redhead, N.J., Hill, R.E., Artavanis-Tsakonas, S. Nat. Genet. (1992)
- Functional relationships between Notch, Su(H) and the bHLH genes of the E(spl) complex: the E(spl) genes mediate only a subset of Notch activities during imaginal development. de Celis, J.F., de Celis, J., Ligoxygakis, P., Preiss, A., Delidakis, C., Bray, S. Development (1996)
- Unidirectional Notch signaling depends on continuous cleavage of Delta. Sapir, A., Assa-Kunik, E., Tsruya, R., Schejter, E., Shilo, B.Z. Development (2005)
- Scabrous and Gp150 are endosomal proteins that regulate Notch activity. Li, Y., Fetchko, M., Lai, Z.C., Baker, N.E. Development (2003)
- Refinement of wingless expression by a wingless- and notch-responsive homeodomain protein, defective proventriculus. Nakagoshi, H., Shirai, T., Nabeshima, Y., Matsuzaki, F. Dev. Biol. (2002)
- Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless. Barolo, S., Stone, T., Bang, A.G., Posakony, J.W. Genes Dev. (2002)
- Neuralized is essential for a subset of Notch pathway-dependent cell fate decisions during Drosophila eye development. Lai, E.C., Rubin, G.M. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Echinoid synergizes with the Notch signaling pathway in Drosophila mesothorax bristle patterning. Escudero, L.M., Wei, S.Y., Chiu, W.H., Modolell, J., Hsu, J.C. Development (2003)
- In vitro reconstitution of the modulation of Drosophila Notch-ligand binding by Fringe. Xu, A., Haines, N., Dlugosz, M., Rana, N.A., Takeuchi, H., Haltiwanger, R.S., Irvine, K.D. J. Biol. Chem. (2007)
- Genetic and molecular characterization of a Notch mutation in its Delta- and Serrate-binding domain in Drosophila. de Celis, J.F., Barrio, R., del Arco, A., García-Bellido, A. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Genetic screen for modifiers of the rough eye phenotype resulting from overexpression of the Notch antagonist hairless in Drosophila. Schreiber, S.L., Preiss, A., Nagel, A.C., Wech, I., Maier, D. Genesis (2002)
- Ectopic expression of lunatic Fringe leads to downregulation of Serrate-1 in the developing chick neural tube; analysis using in ovo electroporation transfection technique. Sakamoto, K., Nakamura, H., Takagi, M., Takeda, S., Katsube, K. FEBS Lett. (1998)
- Molecular analysis of a cellular decision during embryonic development of Drosophila melanogaster: epidermogenesis or neurogenesis. Campos-Ortega, J.A., Knust, E. Eur. J. Biochem. (1990)