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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Igkv8-28  -  immunoglobulin kappa variable 8-28

Mus musculus

Synonyms: ENSMUSG00000073023, ENSMUSG00000076579, Gm10884
 
 
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Disease relevance of Igkv8-28

  • We found that lymphocyte numbers underwent a dose-dependent, four-phased change: cellular depletion (Days 1-2), followed by rapid hyperplasia (Days 3-4), incremental cell number reduction (Days 5-7), and a subsequent subacute phase of elevated lymphocyte numbers (Days 8-28) [1].
 

High impact information on Igkv8-28

  • RU26988/RU28362 increased alpha-LA to a maximum of 3-6-fold basal at approximately 3 nM, well below the Kd (37 degrees C) for Type II receptors (8-28 nM); levels fell progressively with increasing concentration of ligand, returning to baseline by 30-300 nM [2].
 

Biological context of Igkv8-28

  • Thus, response to ozone inhalation involves an acute phase (Days 1-7) characterized by a hyperplastic increase in cell mass and a subacute phase (Days 8-28) characterized by functional changes in lymphocyte reactivity [1].

References

  1. T-cell activation in pulmonary lymph nodes of mice exposed to ozone. Dziedzic, D., White, H.J. Environmental research. (1986) [Pubmed]
  2. Steroid receptors, and the generation of closely coupled/biphasic dose-response curves. Quirk, S.J., Funder, J.W. J. Steroid Biochem. (1988) [Pubmed]
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