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Gene Review

PlexB  -  Plexin B

Drosophila melanogaster

Synonyms: CG17245, Dmel\CG17245, PLEXB, Plexin-B, plex, ...
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High impact information on plexB


Other interactions of plexB

  • These results suggest a model whereby PlexB mediates repulsion by coordinately regulating two small GTPases in opposite directions: PlexB binds to Rac(GTP) and downregulates its output by blocking its access to PAK and, at the same time, binds to and increases the output of RhoA [2].


  1. Plexin A is a neuronal semaphorin receptor that controls axon guidance. Winberg, M.L., Noordermeer, J.N., Tamagnone, L., Comoglio, P.M., Spriggs, M.K., Tessier-Lavigne, M., Goodman, C.S. Cell (1998) [Pubmed]
  2. Plexin B mediates axon guidance in Drosophila by simultaneously inhibiting active Rac and enhancing RhoA signaling. Hu, H., Marton, T.F., Goodman, C.S. Neuron (2001) [Pubmed]
  3. Drosophila Plexin B is a Sema-2a receptor required for axon guidance. Ayoob, J.C., Terman, J.R., Kolodkin, A.L. Development (2006) [Pubmed]
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