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Gene Review

Plxnb1  -  plexin B1

Mus musculus

Synonyms: 2900002G15Rik, AU042020, Kiaa0407, Plexin-B1, mKIAA0407
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High impact information on Plxnb1

  • The class IV semaphorin CD100/Sema4D differentially utilizes two distinct receptors: plexin-B1 in nonlymphoid tissues, such as brain and kidney, and CD72 in lymphoid tissues [1].
  • In addition, binding of Sema 4D to Plexin B1 stimulates the tyrosine kinase activity of Met, resulting in tyrosine phosphorylation of both receptors [2].
  • Mutation of either the PDZ domain in LARG or the PDZ binding site in plexin-B1 eliminates the interaction [3].
  • Moreover, we prove that biologic effects elicited by Plexin B1 require coupling and activation of the Met tyrosine kinase [4].
  • Moreover, plexin-B1 and its ligand Sema4D are expressed in complementary patterns in several regions such as the developing neopallial cortex, the dorsal root ganglia and the spinal cord over embryonic stages [5].

Biological context of Plxnb1

  • Plexin-B1 gene expression increased significantly by 126.8% +/- 38% in the pregnant mare serum gonadotropin-treated group and increased by 98.7% +/- 15.2 and 262.2% +/- 65.4% in the hCG-treated group 6 h and 24 h after injection, respectively (ANOVA; P < .05) [6].

Anatomical context of Plxnb1

  • Plxnb1 and Plxnb2 are expressed in the immature glomeruli and mesenchyme of the developing kidney [7].
  • CONCLUSION: In the ovarian follicle, the effect of Plexin-B1 is mediated by sema-4D [8].
  • Semaphorin-4D/Plexin-B1 binding provides attractive and repulsive cues for the navigation of axonal growth cones, and new studies suggest that this system also plays a role in the regulation of the biological functions of endothelial cells, specifically in the control of angiogenesis [8].
  • RESULT(S): Plexin-B1 was expressed in the mouse ovary mostly in the granulosa cells [6].

Regulatory relationships of Plxnb1

  • Our results further suggest that the RhoA-ROCK pathway, which is activated downstream of plexin B1, mediates these inhibitory morphogenetic effects of Sema4d and suppresses branch-promoting signalling effectors of the plexin B1 signalling complex [9].

Other interactions of Plxnb1

  • We have done an extensive non-radioactive in situ hybridisation survey of Plxna1-a4, Plxnb1 -b3 and Plxnc1 in E14 mouse embryo [7].

Analytical, diagnostic and therapeutic context of Plxnb1


  1. The class IV semaphorin CD100 plays nonredundant roles in the immune system: defective B and T cell activation in CD100-deficient mice. Shi, W., Kumanogoh, A., Watanabe, C., Uchida, J., Wang, X., Yasui, T., Yukawa, K., Ikawa, M., Okabe, M., Parnes, J.R., Yoshida, K., Kikutani, H. Immunity (2000) [Pubmed]
  2. The semaphorin 4D receptor controls invasive growth by coupling with Met. Giordano, S., Corso, S., Conrotto, P., Artigiani, S., Gilestro, G., Barberis, D., Tamagnone, L., Comoglio, P.M. Nat. Cell Biol. (2002) [Pubmed]
  3. The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG. Aurandt, J., Vikis, H.G., Gutkind, J.S., Ahn, N., Guan, K.L. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  4. Sema4D induces angiogenesis through Met recruitment by Plexin B1. Conrotto, P., Valdembri, D., Corso, S., Serini, G., Tamagnone, L., Comoglio, P.M., Bussolino, F., Giordano, S. Blood (2005) [Pubmed]
  5. Plexin-B family members demonstrate non-redundant expression patterns in the developing mouse nervous system: an anatomical basis for morphogenetic effects of Sema4D during development. Worzfeld, T., Püschel, A.W., Offermanns, S., Kuner, R. Eur. J. Neurosci. (2004) [Pubmed]
  6. Expression of plexin-B1 in the mouse ovary and its possible role in follicular development. Regev, A., Goldman, S., Shalev, E. Fertil. Steril. (2005) [Pubmed]
  7. The expression of plexins during mouse embryogenesis. Perälä, N.M., Immonen, T., Sariola, H. Gene Expr. Patterns (2005) [Pubmed]
  8. Semaphorin-4D (Sema-4D), the Plexin-B1 ligand, is involved in mouse ovary follicular development. Regev, A., Goldman, S., Shalev, E. Reprod. Biol. Endocrinol. (2007) [Pubmed]
  9. A functional role for semaphorin 4D/plexin B1 interactions in epithelial branching morphogenesis during organogenesis. Korostylev, A., Worzfeld, T., Deng, S., Friedel, R.H., Swiercz, J.M., Vodrazka, P., Maier, V., Hirschberg, A., Ohoka, Y., Inagaki, S., Offermanns, S., Kuner, R. Development (2008) [Pubmed]
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