Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Ephrin - CG1862 gene product from transcript CG1862-RC

Drosophila melanogaster

Synonyms: CG1862, Dmel\CG1862, ephrin, lincRNA.922

Tepass, U. et al., Salsi, V. et al., Boyle, M. et al., Bossing, T. et al.

Tepass, Godt, Winklbauer,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Ephrin

Further, several examples demonstrate that cell sorting in vivo can be driven by Eph/ephrin signalling and by the differential expression of cadherins that modulate cell adhesion and motility [1].
Thus, Eph/Ephrin signaling acts to guide a subset of mushroom body branches to their correct synaptic targets [2].
Ephrin tyrosine kinase receptors and ephrins have been proposed as Hox targets, and recently, evidence was gained for their role in limb development [3].

Other interactions of Ephrin

Ephrin/Eph signalling is crucial for axonal pathfinding in vertebrates and invertebrates [4].

References

Cell sorting in animal development: signalling and adhesive mechanisms in the formation of tissue boundaries. Tepass, U., Godt, D., Winklbauer, R. Curr. Opin. Genet. Dev. (2002) [Pubmed]
Drosophila Eph receptor guides specific axon branches of mushroom body neurons. Boyle, M., Nighorn, A., Thomas, J.B. Development (2006) [Pubmed]
Hoxd13 and Hoxa13 directly control the expression of the EphA7 Ephrin tyrosine kinase receptor in developing limbs. Salsi, V., Zappavigna, V. J. Biol. Chem. (2006) [Pubmed]
Dephrin, a transmembrane ephrin with a unique structure, prevents interneuronal axons from exiting the Drosophila embryonic CNS. Bossing, T., Brand, A.H. Development (2002) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.