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Gene Review

chm  -  chameau

Drosophila melanogaster

Synonyms: CG5229, Chm, Dmel\CG5229, HAT, HAT1, ...
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High impact information on chm

  • Activating the pathway stimulates the HAT function of Chameau, promoting histone H4 acetylation and target gene transcription [1].
  • Tethering Rpd3 or Polycomb proteins to the origin decreased its activity, whereas tethering the Chameau acetyltransferase increased origin activity [2].


  1. Chameau HAT and DRpd3 HDAC function as antagonistic cofactors of JNK/AP-1-dependent transcription during Drosophila metamorphosis. Miotto, B., Sagnier, T., Berenger, H., Bohmann, D., Pradel, J., Graba, Y. Genes Dev. (2006) [Pubmed]
  2. Chromatin regulates origin activity in Drosophila follicle cells. Aggarwal, B.D., Calvi, B.R. Nature (2004) [Pubmed]
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