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Gene Review

sun  -  stunted

Drosophila melanogaster

Synonyms: ATP5E, BcDNA:RE19513, BcDNA:RH48911, CG9032, Dmel\CG9032, ...
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High impact information on sun

  • We conclude that the Stunted-Methuselah system is involved in the control of animal ageing [1].
  • We examined the adult drop-dead mutant brain prior to onset of symptoms and found that many glial cells have stunted processes, whereas neuronal morphology is essentially normal [2].
  • Mice heterozygous for a null mutation in Cdx2 exhibit a variable phenotype including tail abnormalities, stunted growth and a homeotic shift of vertebrae [3].
  • The stunted growth of Pdp1(p205) larvae is accompanied by defects in mitosis and endoreplication similar to that associated with nutritional deprivation [4].
  • We describe the maternal-effect and zygotic phenotypes of null mutations in the Drosophila gene for the epsilon-subunit of mitochondrial ATP synthase, stunted (sun) [5].

Biological context of sun

  • Here we report the identification and characterization of two endogenous peptide ligands of Methuselah, designated Stunted A and B. Flies with mutations in the gene encoding these ligands show an increase in lifespan and resistance to oxidative stress [1].


  1. The endogenous ligand Stunted of the GPCR Methuselah extends lifespan in Drosophila. Cvejic, S., Zhu, Z., Felice, S.J., Berman, Y., Huang, X.Y. Nat. Cell Biol. (2004) [Pubmed]
  2. Defective glia in the Drosophila brain degeneration mutant drop-dead. Buchanan, R.L., Benzer, S. Neuron (1993) [Pubmed]
  3. CDX2, a human homologue of Drosophila caudal, is mutated in both alleles in a replication error positive colorectal cancer. Wicking, C., Simms, L.A., Evans, T., Walsh, M., Chawengsaksophak, K., Beck, F., Chenevix-Trench, G., Young, J., Jass, J., Leggett, B., Wainwright, B. Oncogene (1998) [Pubmed]
  4. The Drosophila Par domain protein I gene, Pdp1, is a regulator of larval growth, mitosis and endoreplication. Reddy, K.L., Rovani, M.K., Wohlwill, A., Katzen, A., Storti, R.V. Dev. Biol. (2006) [Pubmed]
  5. The epsilon-subunit of mitochondrial ATP synthase is required for normal spindle orientation during the Drosophila embryonic divisions. Kidd, T., Abu-Shumays, R., Katzen, A., Sisson, J.C., Jiménez, G., Pinchin, S., Sullivan, W., Ish-Horowicz, D. Genetics (2005) [Pubmed]
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