Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

eIF5B - CG10840 gene product from transcript...

Drosophila melanogaster

Synonyms: A1, CG10840, CG14970, Dmel\CG10840, Eif5b, ...

Johnstone, O. et al., Carrera, P. et al.

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Disease relevance of eIF5B

Reduction in Vas-eIF5B interaction during oogenesis leads to female sterility, with phenotypes similar to a vas null mutation [1].

High impact information on eIF5B

Mutations in other translation initiation factors do not enhance the vas phenotype, suggesting that dIF2 has a particular role in germ plasm function [2].
In addition, we show that reduction in Vas-eIF5B interaction virtually abolishes germ cell formation in embryos, while producing a less severe effect on somatic posterior patterning [1].

Other interactions of eIF5B

Interaction with eIF5B is essential for Vasa function during development [1].

References

Interaction with eIF5B is essential for Vasa function during development. Johnstone, O., Lasko, P. Development (2004) [Pubmed]
VASA mediates translation through interaction with a Drosophila yIF2 homolog. Carrera, P., Johnstone, O., Nakamura, A., Casanova, J., Jäckle, H., Lasko, P. Mol. Cell (2000) [Pubmed]

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AgaP_AGAP004824	Anopheles gambiae str. PEST
MGG_06066	Magnaporthe oryzae 70-15
NCU05270	Neurospora crassa OR74A

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