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Gene Review:

Sara - Smad anchor for receptor activation

Drosophila melanogaster

Synonyms: CG15667, Dmel\CG15667, SARA, dSARA, sara

Bennett, D. et al., Miyazono, K. et al.

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High impact information on Sara

Together these data suggest that PP1c is targeted to Dpp receptor complexes by Sara, where it acts as a negative regulator of Dpp signaling by affecting the phosphorylation state of the type I receptor [1].
Receptor-regulated Smads (R-Smads) are anchored to the cell membrane by interaction with membrane-bound proteins, including Smad anchor for receptor activation (SARA) [2].

References

PP1 binds Sara and negatively regulates Dpp signaling in Drosophila melanogaster. Bennett, D., Alphey, L. Nat. Genet. (2002) [Pubmed]
TGF-beta signaling by Smad proteins. Miyazono, K., ten Dijke, P., Heldin, C.H. Adv. Immunol. (2000) [Pubmed]

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