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Gene Review

HMGA1  -  high mobility group AT-hook 1

Canis lupus familiaris

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Disease relevance of HMGA1

  • Human and murine HMGA1 non-histone proteins participate in a wide variety of cellular processes including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the induction of neoplastic transformation and promotion of metastatic progression of cancer cells [1].

High impact information on HMGA1

  • In this study, we characterised the molecular structure of the canine HMGA1 cDNA, its splice variants and predicted proteins HMGA1a and HMGA1b [1].
  • Over-expression of the proteins of HMGA1 is characteristic for various malignant tumours suggesting a relation between high titer of the protein and the neoplastic phenotype [1].


  1. The canine HMGA1. Murua Escobar, H., Soller, J.T., Richter, A., Meyer, B., Winkler, S., Flohr, A.M., Nolte, I., Bullerdiek, J. Gene (2004) [Pubmed]
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