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Gene Review

HMGA1  -  high mobility group AT-hook 1

Gallus gallus

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Disease relevance of HMGA1

  • In this study, we have cloned chicken HMGA1, and used the chicken DT40 B-cell lymphoma line to generate cells lacking HMGA1, HMGA2 and both in combination [1].
  • HMGA1 nonhistone proteins are reported to participate in various cellular processes including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the induction of neoplastic transformation and promotion of metastatic progression of cancer cells [2].

High impact information on HMGA1

  • We characterize the molecular structure of the canine HMGA1 cDNA, its splice variants, and predicted proteins HMGA1a and HMGA1b [2].
  • Overexpression of HMGA1 was shown to be characteristic for various malignant tumors, suggesting a relation between the neoplastic phenotype and a high titer of the protein [2].


  1. Construction and analysis of cells lacking the HMGA gene family. Beitzel, B., Bushman, F. Nucleic Acids Res. (2003) [Pubmed]
  2. "Best friends" sharing the HMGA1 gene: comparison of the human and canine HMGA1 to orthologous other species. Murua Escobar, H., Soller, J.T., Richter, A., Meyer, B., Winkler, S., Bullerdiek, J., Nolte, I. J. Hered. (2005) [Pubmed]
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