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Gene Review:

C5AR - C5a anaphylatoxin receptor

Ovis aries

Cain, S.A. et al., Tsuji, R.F. et al.

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Disease relevance of C5aR

Preferential suppression of delayed-type hypersensitivity by L-156,602, a C5a receptor antagonist [1].

High impact information on C5aR

The cyclic C5a receptor antagonist, phenylalanine [L-ornithine-proline-D-cyclohexylalanine-tryptophan-arginine] (F-[OPchaWR]), has approximately 1000-fold less affinity for the C5a receptor (C5aR) on murine polymorphonuclear leukocytes than on human [2].

References

Preferential suppression of delayed-type hypersensitivity by L-156,602, a C5a receptor antagonist. Tsuji, R.F., Uramoto, M., Koshino, H., Tsuji, N.M., Magae, J., Nagai, K., Yamasaki, M. Biosci. Biotechnol. Biochem. (1992) [Pubmed]
Modulation of ligand selectivity by mutation of the first extracellular loop of the human C5a receptor. Cain, S.A., Woodruff, T.M., Taylor, S.M., Fairlie, D.P., Sanderson, S.D., Monk, P.N. Biochem. Pharmacol. (2001) [Pubmed]

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