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Gene Review:

AHR - aryl hydrocarbon receptor

Ovis aries

Vorderstrasse, B.A. et al., Abraham, W.M. et al., Tkáciková, L. et al.

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High impact information on AHR

The results of these studies suggest that the absence of the AhR does not impact the function of the immune system, but confirm the findings of previous studies that have indicated the AhR plays an obligatory role in TCDD-induced immune suppression [1].
Low-risk genotypes were found in 67.7% of sheep (ARR/ARQ 45.2, ARR/ARR 10.9, ARR/AHQ 5.7, ARQ/ARQ 4.9, AHQ/AHQ 0.7, ARR/AHR 0.3) [2].

Analytical, diagnostic and therapeutic context of AHR

These findings are similar to previous data obtained in this animal model with other 5-LO inhibitors (blockade of the LAR and AHR) and COX inhibitors (blockade of AHR) [3].

References

Aryl hydrocarbon receptor-deficient mice generate normal immune responses to model antigens and are resistant to TCDD-induced immune suppression. Vorderstrasse, B.A., Steppan, L.B., Silverstone, A.E., Kerkvliet, N.I. Toxicol. Appl. Pharmacol. (2001) [Pubmed]
The PrP genotype of sheep of the improved Valachian breed. Tkáciková, L., Hanusovská, E., Novák, M., Arvayová, M., Mikula, I. Folia Microbiol. (Praha) (2003) [Pubmed]
The effects of ML 3000 on antigen-induced responses in sheep. Abraham, W.M., Laufer, S., Tries, S. Pulmonary pharmacology & therapeutics. (1997) [Pubmed]

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