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Gene Review:

GluRIID - Glutamate receptor IID

Drosophila melanogaster

Synonyms: CG18039, CT13538, DGluRIID, DKaiR-IA, DmelGluRIID, ...

Featherstone, D.E. et al., Qin, G. et al.

Featherstone, Rushton, Rohrbough, Liebl, Karr, Sheng, Rodesch, Broadie,

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High impact information on KaiRIA

Here we identify a fourth and a fifth subunit expressed in the neuromuscular system, which we name GluRIID and GluRIIE [1].
Thus, we conclude that GluRIID is essential for the assembly and/or stabilization of glutamate receptors in the NMJ [2].
In null brec mutant embryos, the frequency of periodic excitatory currents in motor neurons is significantly reduced, demonstrating that CNS motor pattern activity is regulated by GluRIID [2].
Homozygous brec mutants are embryonic lethal, paralyzed, and show no detectable synaptic transmission at the glutamatergic neuromuscular junction (NMJ) [2].

Analytical, diagnostic and therapeutic context of KaiRIA

In the NMJ of null brec mutants, all known glutamate receptor subunits are undetectable by immunocytochemistry, and all functional glutamate receptors are eliminated [2].

References

Four different subunits are essential for expressing the synaptic glutamate receptor at neuromuscular junctions of Drosophila. Qin, G., Schwarz, T., Kittel, R.J., Schmid, A., Rasse, T.M., Kappei, D., Ponimaskin, E., Heckmann, M., Sigrist, S.J. J. Neurosci. (2005) [Pubmed]
An essential Drosophila glutamate receptor subunit that functions in both central neuropil and neuromuscular junction. Featherstone, D.E., Rushton, E., Rohrbough, J., Liebl, F., Karr, J., Sheng, Q., Rodesch, C.K., Broadie, K. J. Neurosci. (2005) [Pubmed]

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