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Gene Review:

ninl - ninein-like

Xenopus laevis

Casenghi, M. et al., Rapley, J. et al.

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High impact information on Nlp

X-Nlp is a 213-kDa mother centriole-specific protein, implicating it in microtubule anchoring [1].
Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation [2].
Nlp interacts with two components of the gamma-tubulin ring complex and stimulates microtubule nucleation [2].
We propose that Nlp plays an important role in microtubule organization during interphase, and that the activation of Plk1 at the onset of mitosis triggers the displacement of Nlp from the centrosome, allowing the establishment of a mitotic scaffold with enhanced microtubule nucleation activity [2].

Other interactions of Nlp

Plk1 phosphorylates Nlp and disrupts both its centrosome association and its gamma-tubulin interaction [2].

References

Coordinate regulation of the mother centriole component nlp by nek2 and plk1 protein kinases. Rapley, J., Baxter, J.E., Blot, J., Wattam, S.L., Casenghi, M., Meraldi, P., Nigg, E.A., Fry, A.M. Mol. Cell. Biol. (2005) [Pubmed]
Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation. Casenghi, M., Meraldi, P., Weinhart, U., Duncan, P.I., Körner, R., Nigg, E.A. Dev. Cell (2003) [Pubmed]

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