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Gene Review:

CONA - conA-induced cell proliferation

Sus scrofa

Ferreira, B.R. et al., Farnum, C.E. et al.

Ferreira, Szabó, Cavassani, Bechara, Silva,

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High impact information on CONA

We found that T-cells from guinea pigs infested with adult ticks proliferate vigorously in the presence of concanavalin A (ConA), whereas ConA-induced cell proliferation of tick-infested mice and dogs was significantly decreased at 43.1 and 94.0%, respectively, compared to non-infested controls [1].
Pericellular glyconconjugtes that bind RCA-I and concanvalin A (CONA) after periodic acid oxidation, and which were sensitive to trypsin but not to chondroitinase or hyaluronidase, were present in the hypertrophic cell zone [2].

References

Antigens from Rhipicephalus sanguineus ticks elicit potent cell-mediated immune responses in resistant but not in susceptible animals. Ferreira, B.R., Szabó, M.J., Cavassani, K.A., Bechara, G.H., Silva, J.S. Vet. Parasitol. (2003) [Pubmed]
In situ localization of lectin-binding glycoconjugates in the matrix of growth-plate cartilage. Farnum, C.E., Wilsman, N.J. Am. J. Anat. (1986) [Pubmed]

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