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MeSH Review

Guinea Pigs

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Disease relevance of Guinea Pigs


Psychiatry related information on Guinea Pigs


High impact information on Guinea Pigs

  • The gene (MDC) encodes a 524-amino acid metalloprotease-like, disintegrin-like and cysteine-rich protein with sequence similarity to members of the snake-venom metalloprotease/disintegrin family and guinea-pig sperm-surface protein PH-30 [11].
  • We have investigated the possibility that the inflammatory peptide bradykinin, normally degraded by ACE, causes sensitization of airway sensory nerves and an enhancement of the cough reflex in conscious guinea pigs [12].
  • Treatment of guinea pigs for two weeks with captopril led to an increased cough response to inhaled citric acid, which was prevented by concomitant treatment with the bradykinin receptor antagonist icatibant [12].
  • In frog ventricular muscle and guinea-pig hippocampal neurons, cGMP inhibits voltage-activated Ca2+ currents by stimulating phosphodiesterase activity and reducing intracellular cyclic AMP; however, this mechanism is not involved in the action of cGMP on other channels or on Ca2+ channels in other cells [13].
  • Here we report that in frog, rat, and guinea pig ventricular myocytes ICa increases slowly and monophasically in response to isoproterenol [14].

Chemical compound and disease context of Guinea Pigs


Biological context of Guinea Pigs


Anatomical context of Guinea Pigs


Associations of Guinea Pigs with chemical compounds


Gene context of Guinea Pigs

  • Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation [34].
  • Guinea pig lungs perfused with Ringers-albumin were challenged with TNF alpha (1,000 U/ml) for 90 min, followed by addition of fresh perfusate containing 2 x 10(7) human PMN [35].
  • The CC chemokine eotaxin, identified in guinea pigs and also recently in mice, may be a key element for the selective recruitment of eosinophils to certain inflamed tissues [36].
  • We tested whether GW701897B, an antagonist of CCR3 (the receptor for eotaxin as well as a group of eosinophil active chemokines), affected vagal reactivity and M2R function in ovalbumin-challenged guinea pigs [37].
  • The ability of plasma from various animal species to displace labeled human LCAT from goat anti-human LCAT could be ranked in the following order: man and sheep > nonhuman primates > cat or dog > pig > rabbit or guinea pig > mouse > rat [38].

Analytical, diagnostic and therapeutic context of Guinea Pigs


  1. Allergic encephalomyelitis induced in guinea pigs by a peptide from the NH2-terminus of bovine P2 protein. Brostoff, S.W., Powers, J.M., Weise, M.J. Nature (1980) [Pubmed]
  2. N-methyl-D-aspartate antagonists limit aminoglycoside antibiotic-induced hearing loss. Basile, A.S., Huang, J.M., Xie, C., Webster, D., Berlin, C., Skolnick, P. Nat. Med. (1996) [Pubmed]
  3. Role of platelet-activating factor-acether in mediating guinea pig anaphylaxis. Darius, H., Lefer, D.J., Smith, J.B., Lefer, A.M. Science (1986) [Pubmed]
  4. Regression of tumors in guinea pigs after treatment with synthetic muramyl dipeptides and trehalose dimycolate. McLaughlin, C.A., Schwartzman, S.M., Horner, B.L., Jones, G.H., Moffatt, J.G., Nestor, J.J., Tegg, D. Science (1980) [Pubmed]
  5. Stereospecific and nonstereospecific effects of (+)- and (-)-morphine: evidence for a new class of receptors? Jacquet, Y.F., Klee, W.A., Rice, K.C., Iijima, I., Minamikawa, J. Science (1977) [Pubmed]
  6. Learned histamine release. Russell, M., Dark, K.A., Cummins, R.W., Ellman, G., Callaway, E., Peeke, H.V. Science (1984) [Pubmed]
  7. 5-HT1A receptor activation increases hippocampal acetylcholine efflux and motor activity in the guinea pig: agonist efficacy influences functional activity in vivo. Wilkinson, L.O., Middlemiss, D.N., Hutson, P.H. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  8. Characterization of alpha-adrenergic receptors in guinea pig cerebral cortex: effect of chronic antidepressant treatments. Hu, H.Y., Davis, J.M., Pandey, G.N. Psychopharmacology (Berl.) (1981) [Pubmed]
  9. Relaxin stimulates interstitial collagenase activity in cultured uterine cervical cells from nonpregnant and pregnant but not immature guinea pigs; estradiol-17 beta restores relaxin's effect in immature cervical cells. Mushayandebvu, T.I., Rajabi, M.R. Biol. Reprod. (1995) [Pubmed]
  10. Ascorbic acid chronic alcohol consumption in the guinea pig. Susick, R.L., Abrams, G.D., Zurawski, C.A., Zannoni, V.G. Toxicol. Appl. Pharmacol. (1986) [Pubmed]
  11. A novel metalloprotease/disintegrin-like gene at 17q21.3 is somatically rearranged in two primary breast cancers. Emi, M., Katagiri, T., Harada, Y., Saito, H., Inazawa, J., Ito, I., Kasumi, F., Nakamura, Y. Nat. Genet. (1993) [Pubmed]
  12. Bradykinin-evoked sensitization of airway sensory nerves: a mechanism for ACE-inhibitor cough. Fox, A.J., Lalloo, U.G., Belvisi, M.G., Bernareggi, M., Chung, K.F., Barnes, P.J. Nat. Med. (1996) [Pubmed]
  13. Potassium channel stimulation by natriuretic peptides through cGMP-dependent dephosphorylation. White, R.E., Lee, A.B., Shcherbatko, A.D., Lincoln, T.M., Schonbrunn, A., Armstrong, D.L. Nature (1993) [Pubmed]
  14. Sympathetic regulation of cardiac calcium current is due exclusively to cAMP-dependent phosphorylation. Hartzell, H.C., Méry, P.F., Fischmeister, R., Szabo, G. Nature (1991) [Pubmed]
  15. Hemagglutination by purified type I Escherichia coli pili. Salit, I.E., Gotschlich, E.C. J. Exp. Med. (1977) [Pubmed]
  16. Differential stimulation of murine lymphoma growth in vitro by normal and BCG-activated macrophages. Nathan, C.F., Terry, W.D. J. Exp. Med. (1975) [Pubmed]
  17. In vivo neutralization of eosinophil-derived major basic protein inhibits antigen-induced bronchial hyperreactivity in sensitized guinea pigs. Lefort, J., Nahori, M.A., Ruffie, C., Vargaftig, B.B., Pretolani, M. J. Clin. Invest. (1996) [Pubmed]
  18. Active immunization with lipopolysaccharide Pseudomonas antigen for chronic Pseudomonas bronchopneumonia in guinea pigs. Pennington, J.E., Hickey, W.F., Blackwood, L.L., Arnaut, M.A. J. Clin. Invest. (1981) [Pubmed]
  19. Feline leukemia virus envelope glycoprotein vaccine: preparation and evaluation of immunizing potency in guinea pig and cat. Salerno, R.A., Lehman, E.D., Larson, V.M., Hilleman, M.R. J. Natl. Cancer Inst. (1978) [Pubmed]
  20. Benzodiazepines antagonize cholecystokinin-induced activation of rat hippocampal neurones. Bradwejn, J., de Montigny, C. Nature (1984) [Pubmed]
  21. Synaptosomes possess an exocytotic pool of glutamate. Nicholls, D.G., Sihra, T.S. Nature (1986) [Pubmed]
  22. Intracellular studies showing modulation of facial motoneurone excitability by serotonin. VanderMaelen, C.P., Aghajanian, G.K. Nature (1980) [Pubmed]
  23. Stimulated vasopressin synthesis by a fetal hypothalamic factor. Pearson, D.B., Goodman, R., Sachs, H. Science (1975) [Pubmed]
  24. Release of adenosine by activation of NMDA receptors in the hippocampus. Manzoni, O.J., Manabe, T., Nicoll, R.A. Science (1994) [Pubmed]
  25. Novel form of drug-dependence--on adenosine in guinea pig ileum. Collier, H.O., Tucker, J.F. Nature (1983) [Pubmed]
  26. Adenosine mediates a slow hyperpolarizing synaptic potential in autonomic neurones. Akasu, T., Shinnick-Gallagher, P., Gallagher, J.P. Nature (1984) [Pubmed]
  27. Specific binding of 3H-tiotidine to histamine H2 receptors in guinea pig cerebral cortex. Gajtkowski, G.A., Norris, D.B., Rising, T.J., Wood, T.P. Nature (1983) [Pubmed]
  28. Prostaglandin synthesis in different phases of phagocytosis in lung macrophages. Hsueh, W., Gonzalez-Crussi, F., Hanneman, E. Nature (1980) [Pubmed]
  29. Ouabain stimulation of noradrenaline transport in guinea pig heart. Sharma, V.K., Pottick, L.A., Banerjee, S.P. Nature (1980) [Pubmed]
  30. Dihydroouabain is an antagonist of ouabain inotropic action. Godfraind, T., Ghysel-Burton, J., De Pover, A. Nature (1982) [Pubmed]
  31. Recombinant human lipocortin 1 inhibits thromboxane release from guinea-pig isolated perfused lung. Cirino, G., Flower, R.J., Browning, J.L., Sinclair, L.K., Pepinsky, R.B. Nature (1987) [Pubmed]
  32. Periodate-induced increase in cyclic GMP in mouse and guinea pig splenic cells in association with mitogenesis. Haddox, M.K., Furcht, L.T., Gentry, S.R., Moser, M.E., Stephenson, J.H., Goldberg, N.D. Nature (1976) [Pubmed]
  33. Transglutaminase modifies the carboxy-terminal intracellular region of HLA-A and -B antigens. Pober, J.S., Strominger, J.L. Nature (1981) [Pubmed]
  34. Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation. Jose, P.J., Griffiths-Johnson, D.A., Collins, P.D., Walsh, D.T., Moqbel, R., Totty, N.F., Truong, O., Hsuan, J.J., Williams, T.J. J. Exp. Med. (1994) [Pubmed]
  35. Tumor necrosis factor mediates experimental pulmonary edema by ICAM-1 and CD18-dependent mechanisms. Lo, S.K., Everitt, J., Gu, J., Malik, A.B. J. Clin. Invest. (1992) [Pubmed]
  36. Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils. Ponath, P.D., Qin, S., Ringler, D.J., Clark-Lewis, I., Wang, J., Kassam, N., Smith, H., Shi, X., Gonzalo, J.A., Newman, W., Gutierrez-Ramos, J.C., Mackay, C.R. J. Clin. Invest. (1996) [Pubmed]
  37. Neuronal eotaxin and the effects of CCR3 antagonist on airway hyperreactivity and M2 receptor dysfunction. Fryer, A.D., Stein, L.H., Nie, Z., Curtis, D.E., Evans, C.M., Hodgson, S.T., Jose, P.J., Belmonte, K.E., Fitch, E., Jacoby, D.B. J. Clin. Invest. (2006) [Pubmed]
  38. Radioimmunoassay of human plasma lecithin-cholesterol acyltransferase. Albers, J.J., Adolphson, J.L., Chen, C.H. J. Clin. Invest. (1981) [Pubmed]
  39. A suppressor T-lymphocyte cell line for autoimmune encephalomyelitis. Ellerman, K.E., Powers, J.M., Brostoff, S.W. Nature (1988) [Pubmed]
  40. The molecular basis of opioid receptor function. Simonds, W.F. Endocr. Rev. (1988) [Pubmed]
  41. Spontaneous recovery of rats from experimental allergic encephalomyelitis is dependent on regulation of the immune system by endogenous adrenal corticosteroids. MacPhee, I.A., Antoni, F.A., Mason, D.W. J. Exp. Med. (1989) [Pubmed]
  42. A hemolytic plaque assay for activated murine T cells. Primi, D., Lewis, G.K., Goodman, J.W. J. Exp. Med. (1979) [Pubmed]
  43. IL-1beta and IL-6 excite neurons and suppress nicotinic and noradrenergic neurotransmission in guinea pig enteric nervous system. Xia, Y., Hu, H.Z., Liu, S., Ren, J., Zafirov, D.H., Wood, J.D. J. Clin. Invest. (1999) [Pubmed]
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