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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PARP1  -  poly (ADP-ribose) polymerase 1

Pan troglodytes

 
 
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Disease relevance of PARP1

  • Here, we report that SFN inhibited proliferation of cultured PC-3 human prostate cancer cells by inducing apoptosis that was characterized by appearance of cells with sub-G0/G1 DNA content, formation of cytoplasmic histone associated DNA fragments and cleavage of poly(ADP-ribose)polymerase (PARP) [1].
 

High impact information on PARP1

  • CD437-mediated poly(ADP-ribose) polymerase (PARP) cleavage and apoptosis of HL-60R cells does not require gene transcription or protein synthesis since it occurs in the presence or absence of either actinomycin D or cycloheximide [2].

References

  1. Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo. Singh, A.V., Xiao, D., Lew, K.L., Dhir, R., Singh, S.V. Carcinogenesis (2004) [Pubmed]
  2. Activation of the p38 and JNK/SAPK mitogen-activated protein kinase pathways during apoptosis is mediated by a novel retinoid. Zhang, Y., Huang, Y., Rishi, A.K., Sheikh, M.S., Shroot, B., Reichert, U., Dawson, M., Poirer, G., Fontana, J.A. Exp. Cell Res. (1999) [Pubmed]
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